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Merck

L7895

Sigma-Aldrich

脂多糖 来源于伤寒沙门氏菌

γ-irradiated, BioXtra, suitable for cell culture

别名:

LPS

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About This Item

MDL號碼:
分類程式碼代碼:
12352201
NACRES:
NA.75

生物源

bacterial (Salmonella typhosa)

品質等級

無菌

γ-irradiated

產品線

BioXtra

形狀

lyophilized powder

純化經由

gel-filtration chromatography

技術

cell culture | mammalian: suitable

雜質

<1% Protein (Lowry)

顏色

white to faint yellow

溶解度

water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow

儲存溫度

2-8°C

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應用

来自鼠伤寒沙门氏菌的脂多糖用于细胞培养和细胞结合应用。在小鼠脾细胞培养物中研究了 LPS 在 TNF-α 和 IL-6 分泌中的作用。它被用来研究炎症反应在多发性硬化中的作用。
脂多糖(LPS)是革兰氏阴性细菌细胞壁的特征成分。LPS 及其脂质 A 部分通过 Toll 样受体 4(TLR4)刺激先天免疫系统的细胞,TLR4 是 Toll 样受体蛋白家族的成员,它能识别常见的病原体相关分子模式(PAMP)。

生化/生理作用

脂多糖(LPS)是革兰氏阴性菌细胞壁的特征性成分。LPS及其脂质A部分可通过Toll样受体4(TLR4)刺激先天免疫系统细胞,TLR4是Toll样受体蛋白家族的成员,它能识别常见的病原体相关分子模式(PAMP)。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

D N Dao et al.
Infection and immunity, 72(4), 2067-2074 (2004-03-25)
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as a virulence factor of Mycobacterium tuberculosis, and modification of the terminal arabinan residues of this compound with mannose caps (producing mannosyl-capped LAM [ManLAM]) in M. tuberculosis or with phosphoinositol
Aurélien Godinat et al.
Current protocols in chemical biology, 6(3), 169-189 (2014-09-11)
The great complexity of many human pathologies, such as cancer, diabetes, and neurodegenerative diseases, requires new tools for studies of biological processes on the whole organism level. The discovery of novel biocompatible reactions has tremendously advanced our understanding of basic
Johnathan Ho et al.
PLoS biology, 14(10), e2000117-e2000117 (2016-10-26)
STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IFN-independent activities. Here, we show that
Yasuhisa Ano et al.
Nutrients, 11(9) (2019-09-12)
The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the
Armin Neininger et al.
The Journal of biological chemistry, 277(5), 3065-3068 (2001-12-14)
We demonstrate that lipopolysaccharide-induced tumor necrosis factor (TNF) biosynthesis becomes independent of MAPKAP kinase 2 (MK2) when the AU-rich element (ARE) of the TNF gene is deleted. In spleen cells and macrophages where TNF biosynthesis is restored as a result

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