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Merck
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主要文件

L4040

Sigma-Aldrich

乳铁蛋白 人

recombinant, expressed in rice, Partially iron saturated, ≥90% (SDS-PAGE)

别名:

Growth-inhibiting protein 12, Lactotransferrin, Talalactoferrin

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

human

品質等級

重組細胞

expressed in rice

化驗

≥70% protein basis (Bradford)
≥90% (SDS-PAGE)

形狀

powder

技術

microbiological culture: suitable

溶解度

H2O: soluble 10 mg/mL

UniProt登錄號

儲存溫度

2-8°C

基因資訊

human ... LTF(4057)

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應用

使用乳铁蛋白在铁限制培养基中培养变形链球菌 用于测试乳铁蛋白在体外是否阻碍上皮细胞黏附 同时用于测试血液细胞因子浓度对急性肺炎的诊断价值。

生化/生理作用

乳铁蛋白是一种铁结合蛋白。在结构上与血浆铁转运蛋白转铁蛋白相似;但是乳铁蛋白对铁的亲和力要高得多(250 倍)。在初乳中含量非常丰富,少量也可见于泪液、唾液、粘液分泌物和中性粒细胞的次级颗粒中。由粘膜上皮和中性粒细胞组成,在炎症刺激下由这些细胞释放。细菌的生长被其隔离铁的能力所抑制,也通过其 N 端与脂多糖结合使细菌细胞壁通透性增加。乳铁蛋白可以通过与病毒包膜蛋白紧密结合来抑制病毒感染。这通过阻断结合域阻止了细胞与病毒的融合。乳铁蛋白似乎部分通过刺激中性粒细胞激活剂白细胞介素-8 的释放来激活宿主防御系统。还可能参与抗体和白细胞介素合成、淋巴细胞增殖和补体激活。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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