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About This Item
经验公式（希尔记法）:
C15H14O3
CAS号:
分子量:
242.27
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
生物源
synthetic (organic)
化驗
≥98% (TLC)
形狀
powder
SMILES 字串
CC1(C)CCC2=C(O1)c3ccccc3C(=O)C2=O
InChI
1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
InChI 密鑰
QZPQTZZNNJUOLS-UHFFFAOYSA-N
應用
ββ-拉帕醌已用于：
- 作为抗癌药物，用于Lewis肺癌(LLC)细胞和已分离线粒体的过氧化氢酶抑制型鲁米诺/过氧化氢(HRP)-依赖性化学发光检测
- 作为萘醌类物质，研究其对小鼠粒细胞和巨噬细胞祖细胞生长和分化的影响
- 作为人重组NAD(P)H脱氢酶1(NQO1)酶活研究底物
生化／生理作用
β-Lapachone 是一种天然存在的醌，从具有癌症化学预防属性的重蚁木树 (Tabebuia avellanedae) 的树皮中获得。诱导 HL-60 和人前列腺癌细胞凋亡。
β-拉帕醌主要用作I型DNA拓扑异构酶抑制剂，具有抗真菌、抗细菌、杀锥虫和抗病毒活性。β-拉帕醌也可抑制肺泡巨噬细胞诱导型一氧化氮合酶(iNOS)活性和一氧化氮(NO)生成。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
David Siegel et al.
Biochemical pharmacology, 83(8), 1033-1040 (2012-01-03)
Quinones represent a large and diverse class of antitumor drugs and many quinones are approved for clinical use or are currently undergoing evaluation in clinical trials. For many quinones reduction to the hydroquinone has been shown to play a key
S M Planchon et al.
Cancer research, 55(17), 3706-3711 (1995-09-01)
beta-Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K+ assays. We show that beta-lapachone can induce apoptosis in certain cells, such
Oliver Quevedo et al.
Chemical research in toxicology, 24(12), 2106-2108 (2011-11-19)
β-Lapachone (β-lap) is a promising antitumoral agent. DNA base oxidation and alkylation are among the expected damages by β-lap. Herein, we have explored the role that the homologous recombination pathway (HR), a critical DNA repair process in Saccharomyces cerevisiae, has
Xiumei Huang et al.
Cancer research, 72(12), 3038-3047 (2012-04-26)
Agents, such as β-lapachone, that target the redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), to induce programmed necrosis in solid tumors have shown great promise, but more potent tumor-selective compounds are needed. Here, we report that deoxynyboquinone kills a wide spectrum
Isabella M F Cavalcanti et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 44(3), 332-340 (2011-09-06)
The aim of this study was to encapsulate lapachone (β-lap) or inclusion complex (β-lap:HPβ-CD) in liposomes and to evaluate their physicochemical characteristics. In addition, the investigation of the main aspects of the interaction between β-lap and 2-hydroxypropyl-β-cyclodextrin (HPβ-CD), using both
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