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品質等級
溶解度
H2O: 50 mg/mL
SMILES 字串
Cl.C1CN=C(N1)C2COc3ccccc3O2
InChI
1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChI 密鑰
MYUBYOVCLMEAOH-UHFFFAOYSA-N
基因資訊
human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
應用
Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.
生化／生理作用
α2-adrenoceptor antagonist; I2 imidazoline receptor agonist; I1 imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
訊號詞
Danger
危險聲明
防範說明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Effects of idazoxan on alcohol pharmacokinetics and intoxication: a preliminary human laboratory study
Haass-Koffler C L, et al.
Alcohol, 39(4), 594-602 (2015)
Suk-Yun Kang et al.
The journal of pain : official journal of the American Pain Society, 13(2), 155-166 (2012-01-06)
We previously demonstrated that a single injection of diluted bee venom (DBV) temporarily alleviates thermal hyperalgesia, but not mechanical allodynia, in neuropathic rats. The present study was designed to determine whether repetitive injection of DBV produces more potent analgesic effects
Sidney P Kuo et al.
Neuron, 71(2), 306-318 (2011-07-28)
Inhibitory interneurons across diverse brain regions commonly exhibit spontaneous spiking activity, even in the absence of external stimuli. It is not well understood how stimulus-evoked inhibition can be distinguished from background inhibition arising from spontaneous firing. We found that noradrenaline
Christopher J Barnum et al.
Pharmacology, biochemistry, and behavior, 100(3), 607-615 (2011-10-08)
While L-3,4-dihydroxyphenylalanine (L-DOPA) remains the standard treatment for Parkinson's disease (PD), long-term efficacy is often compromised by L-DOPA-induced dyskinesia (LID). Recent research suggests that targeting the noradrenergic (NE) system may provide relief from both PD and LID, however, most PD
Valerio Mammoli et al.
Bioorganic & medicinal chemistry, 20(7), 2259-2265 (2012-03-01)
Aim of the present study was to obtain novel α(2)-adrenoreceptor (α(2)-AR) antagonists, possibly endowed with subtype-selectivity. Therefore, inspired by the non subtype-selective α(2)-AR antagonist idazoxan, we designed 1,4-dioxane derivatives bearing an aromatic area in position 5 or 6 and the
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