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I4377

2′,3′-O-Isopropylideneguanosine

Name: 2′,3′-O-Isopropylideneguanosine
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₃H₁₇N₅O₅

CAS号:

362-76-5

分子量:

323.30

EC號碼:

206-651-9

MDL號碼:

MFCD00057081

分類程式碼代碼:

41106305

PubChem物質ID:

24896054

NACRES:

NA.51

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Sigma-Aldrich

C122106

胞苷

生物源

synthetic (organic)

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

CC1(C)O[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O1)n3cnc4C(=O)NC(N)=Nc34

InChI

1S/C13H17N5O5/c1-13(2)22-7-5(3-19)21-11(8(7)23-13)18-4-15-6-9(18)16-12(14)17-10(6)20/h4-5,7-8,11,19H,3H2,1-2H3,(H3,14,16,17,20)/t5-,7-,8-,11-/m1/s1

InChI 密鑰

XKPDAYWPKILAMO-IOSLPCCCSA-N

應用

2′,3′-O-Isopropylideneguanosine derivatives may be used as cap analogs.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Synthesis and application of a new 2',3'-isopropylidene guanosine substituted cap analog.

Anilkumar R Kore et al.

Bioorganic & medicinal chemistry letters, 18(17), 4828-4832 (2008-08-08)

The synthesis and biological evaluation of a new cap analog, which is modified at the C2' and C3' positions of N(7)-methylguanosine is reported. The new cap analog, P(1)-2',3'-isopropylidene, 7-methylguanosine-5'P(3)-guanosine-5'triphosphate was assayed with respect to its effects on efficiency of incorporation

"Single Addition" substrates for the synthesis of specific oligoribonucleotides with polynucleotide phosphorylase. Synthesis of 2'-(alpha-methoxyethy) nucleoside 5'-diphosphates.

G N Bennett et al.

Biochemistry, 14(14), 3152-3158 (1975-07-15)

A number of synthetic methods for the preparation of the 2-O-(alpha-methoxyethyl) derivatives of the 5-diphosphates of adenosine, cytidine, guanosine, and uridine have been studied in order to provide nucleotide substrates that can be applied to the synthesis of specific oligoribonucleotides

Hydroxylation of guanine in nucleosides and DNA at the C-8 position by heated glucose and oxygen radical-forming agents.

H Kasai et al.

Environmental health perspectives, 67, 111-116 (1986-08-01)

Heated glucose is mutagenic to Salmonella typhimurium TA 100 in the absence of S-9 mix. For identifying unknown mutagens in heated glucose (dry solid, 200 degrees C, 20 min), reaction with isopropylideneguanosine (IPG) was followed by isolation and characterization of

Detection and identification of mutagens by the adducts formed upon reaction with guanosine derivatives.