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生物源
goat
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
mouse
技術
neutralization: suitable
western blot: suitable
UniProt登錄號
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Il1b(16176)
一般說明
白介素是在细胞损伤或创伤时产生的促炎细胞因子。细胞产生的白介素有两种密切相关的类型,IL-1α和IL-1β是由细菌感染或LPS反应时激活NF-κB转录因子产生的。IL-1α和IL-1β通过1型IL-1受体的信号传导发挥其细胞作用。 IL-1β具有多效活性,并通过将中性粒细胞募集到感染部位,分泌细胞因子和趋化因子以及激活粘连分子来预防感染。 IL-1β的过度产生与许多自身免疫和过敏性疾病有关,例如cryopirin相关的周期性综合征,穆-韦二氏综合征和皮肤病变
。抗白介素-1β抗体可与小鼠IL-1β特异性反应。该抗体与人重组IL-1β显示25%的交叉反应性。
。抗白介素-1β抗体可与小鼠IL-1β特异性反应。该抗体与人重组IL-1β显示25%的交叉反应性。
特異性
该抗体将中和重组小鼠IL-1β的生物活性,但不中和重组人IL-1β的生物活性。该抗体与重组人IL-1β的交叉反应性约为25%。
免疫原
重组小鼠IL-1β。
應用
可以使用抗白介素-1β来中和重组小鼠IL-1β在50皮克/毫升的浓度下对小鼠T辅助细胞D10.G4.1细胞系的生物活性。未观察到重组人IL-1β生物活性的中和。该抗体可在1-2 μg/mL的工作浓度或1:1000的稀释度下用于免疫印迹。在免疫印迹应用中,该抗体与人重组IL-1β表现出25%的交叉反应性。
外觀
从含碳水化合物的磷酸盐缓冲盐水中经0.2 μm过滤的溶液冻中干。
準備報告
使用蛋白G纯化。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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