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I3636

Sigma-Aldrich

吖啶诱变剂ICR 191

别名:

6-氯-9- [3-（2-氯乙胺）丙胺基]-2-甲氧基吖啶 二盐酸盐

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1 G
€396.00

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1 G
€396.00

About This Item

经验公式（希尔记法）:
C19H21Cl2N3O · 2HCl
CAS号:
17070-45-0
分子量:
451.22
Beilstein:
8176205
EC號碼:
241-129-4
MDL號碼:
MFCD00013320
分類程式碼代碼:
12171500
PubChem物質ID:
24896042
NACRES:
NA.32

€396.00

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溶解度

DMSO: soluble

品質等級

200

適合性

suitable for Ames test in Salmonella and E. coli (Frameshift mutagenic standard)

儲存溫度

2-8°C

SMILES 字串

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2c1

InChI

1S/C19H21Cl2N3O.2ClH/c1-25-14-4-6-17-16(12-14)19(23-9-2-8-22-10-7-20)15-5-3-13(21)11-18(15)24-17;;/h3-6,11-12,22H,2,7-10H2,1H3,(H,23,24);2*1H

InChI 密鑰

LMEMIKWTNPWYMI-UHFFFAOYSA-N

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50020I5784P0039
Heparin−biotin sodium salt ≥97%

B9806

Heparin−biotin sodium salt

β-Glycerol phosphate disodium salt pentahydrate ≥98.0% (NT)

50020

β-Glycerol phosphate disodium salt pentahydrate

Ibandronate sodium salt ≥97% (NMR), solid

I5784

Ibandronate sodium salt

PHPS1 sodium salt hydrate ≥98% (HPLC)

P0039

PHPS1 sodium salt hydrate

solubility

H2O: soluble 1 mg/mL, clear, colorless

solubility

H2O: 0.1 g/mL, clear, colorless

solubility

H2O: >10 mg/mL

solubility

DMSO: 10 mg/mL, clear (warmed)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

form

solid

form

solid

form

solid

form

solid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

conjugate

biotin conjugate

conjugate

-

conjugate

-

conjugate

-

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    SLCM3877
    SLCH3541
    SLCH0813
    SLCC5167
    SLCC0100

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    R McKendry et al.
    Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11455-11459 (1991-12-15)
    2fTGH is a human cell line containing the selectable marker guanine phosphoribosyltransferase regulated by alpha interferon (IFN-alpha). Two IFN-alpha-unresponsive mutants were isolated previously at a low frequency (ca. 10(-8)) by selecting mutagenized 2fTGH cells in selective medium containing 6-thioguanine and
    M Watanabe et al.
    Mutation research, 314(1), 27-37 (1994-01-01)
    The specificity of frameshift mutations induced by several classes of chemical mutagens was determined using a collection of mutant E. coli lacZ genes. This collection can detect each of five kinds of specific frameshift events by scoring Lac+ revertant colonies.
    W D Chen et al.
    Journal of the National Cancer Institute, 92(6), 480-485 (2000-03-16)
    Deficiency of DNA mismatch repair is a common feature of cancers exhibiting instability of microsatellite DNA sequences. Cancers with microsatellite instability are recognizable by their high rate of spontaneous frameshift mutations within microsatellite sequences, their resistance to killing by cytotoxic
    K L Dobo et al.
    Mutagenesis, 10(1), 53-58 (1995-01-01)
    In order to investigate the influence of loss of heterozygosity (LOH) events on mutation rate, we studied two closely related human lymphoblastoid cell lines, AHH-1 (h2E1.v2) and MCL-5, which are heterozygous at the tk locus (chromosome 17q23-25). Although they have
    S A Taft et al.
    Environmental and molecular mutagenesis, 23(2), 96-100 (1994-01-01)
    Human TK6 lymphoblasts were treated with the acridine derivative ICR-191, and mutants at the hprt locus were isolated. Mutant hprt cDNA was reverse-transcribed from mRNA, amplified by polymerase chain reaction (PCR), and sequenced. Additions of single G:C base pairs (+1
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