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About This Item
经验公式（希尔记法）:
C19H21Cl2N3O · 2HCl
CAS号:
分子量:
451.22
Beilstein:
8176205
EC號碼:
MDL號碼:
分類程式碼代碼:
12171500
PubChem物質ID:
NACRES:
NA.32
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溶解度
DMSO: soluble
品質等級
適合性
suitable for Ames test in Salmonella and E. coli (Frameshift mutagenic standard)
儲存溫度
2-8°C
SMILES 字串
Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2c1
InChI
1S/C19H21Cl2N3O.2ClH/c1-25-14-4-6-17-16(12-14)19(23-9-2-8-22-10-7-20)15-5-3-13(21)11-18(15)24-17;;/h3-6,11-12,22H,2,7-10H2,1H3,(H,23,24);2*1H
InChI 密鑰
LMEMIKWTNPWYMI-UHFFFAOYSA-N
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訊號詞
Danger
危險分類
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
其他客户在看
R McKendry et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11455-11459 (1991-12-15)
2fTGH is a human cell line containing the selectable marker guanine phosphoribosyltransferase regulated by alpha interferon (IFN-alpha). Two IFN-alpha-unresponsive mutants were isolated previously at a low frequency (ca. 10(-8)) by selecting mutagenized 2fTGH cells in selective medium containing 6-thioguanine and
M Watanabe et al.
Mutation research, 314(1), 27-37 (1994-01-01)
The specificity of frameshift mutations induced by several classes of chemical mutagens was determined using a collection of mutant E. coli lacZ genes. This collection can detect each of five kinds of specific frameshift events by scoring Lac+ revertant colonies.
W D Chen et al.
Journal of the National Cancer Institute, 92(6), 480-485 (2000-03-16)
Deficiency of DNA mismatch repair is a common feature of cancers exhibiting instability of microsatellite DNA sequences. Cancers with microsatellite instability are recognizable by their high rate of spontaneous frameshift mutations within microsatellite sequences, their resistance to killing by cytotoxic
K L Dobo et al.
Mutagenesis, 10(1), 53-58 (1995-01-01)
In order to investigate the influence of loss of heterozygosity (LOH) events on mutation rate, we studied two closely related human lymphoblastoid cell lines, AHH-1 (h2E1.v2) and MCL-5, which are heterozygous at the tk locus (chromosome 17q23-25). Although they have
S A Taft et al.
Environmental and molecular mutagenesis, 23(2), 96-100 (1994-01-01)
Human TK6 lymphoblasts were treated with the acridine derivative ICR-191, and mutants at the hprt locus were isolated. Mutant hprt cDNA was reverse-transcribed from mRNA, amplified by polymerase chain reaction (PCR), and sequenced. Additions of single G:C base pairs (+1
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