I2786
IL-6 human
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
Interleukin-6 human, B cell stimulating factor (BSF-2), IL-6, IL6, hepatocyte stimulating factor (HSF), interferon b2 (IFNb2), interleukin hybridoma/plasmacytoma-1 (IL-HP1), monocyte derived human B cell growth factor, plasmacytoma growth factor (PCT-GF)
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About This Item
推荐产品
product name
Interleukin-6 human, IL-6, recombinant, expressed in E. coli, Carrier Free
生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
>97% (SDS-PAGE)
形狀
lyophilized powder
效力
0.2-2.0 ng/mL Biological Activity EC50
品質
Carrier Free
分子量
26 kDa
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
≤1 EU/μg protein Endotoxin Level
顏色
white
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... IL6(3569)
一般說明
Interleukin-6 (IL-6) is a multi-functional 26 kDa protein originally discovered in the medium of RNA-stimulated fibroblastoid cells1. IL-6 appears to be directly
involved in the immune responses that occur after infection and cellular injury, and it may prove to be as important as IL-1 and TNF-a in regulating the acute phase response2,3.
IL-6 is reportedly produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells, and hepatocytes. IL-6 induces multiple effects as indicated by its numerous synonyms4. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes5. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors6.This product is lyophilized from a 0.2 mm-filtered solution of phosphate buffered saline, pH 7.4, containing a stabilizer.
The product was prepared from raw materials verified to be carrier free.
involved in the immune responses that occur after infection and cellular injury, and it may prove to be as important as IL-1 and TNF-a in regulating the acute phase response2,3.
IL-6 is reportedly produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells, and hepatocytes. IL-6 induces multiple effects as indicated by its numerous synonyms4. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes5. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors6.This product is lyophilized from a 0.2 mm-filtered solution of phosphate buffered saline, pH 7.4, containing a stabilizer.
The product was prepared from raw materials verified to be carrier free.
應用
Human interleukin-6 (IL-6) has been used to study the effects of IL-6, along with IL-8 and IL-1β, on the clot structure of healthy blood.
生化／生理作用
IL-6 is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Simultaneous presence of hypercoagulation and increased clot lysis time due to IL-1beta, IL-6 and IL-8
Janette B, et al.
Cytokine (2018)
A new interleukin with pleiotropic activities.
T Kishimoto et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 9(1), 11-15 (1988-07-01)
J Van Snick et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(24), 9679-9683 (1986-12-01)
A T-cell-derived lymphokine was identified by its ability to support the growth of a subset of B-cell hybridomas. Hybrids that failed to survive in the absence of this molecule represented a major proportion of rat-mouse hybridomas but were very rare
R P Nordan et al.
Journal of immunology (Baltimore, Md. : 1950), 139(3), 813-817 (1987-08-01)
Plasmacytoma growth factor (PCT-GF), a putative macrophage-derived lymphokine essential for the in vitro viability and proliferation of early generation plasmacytomas, was purified from conditioned medium of the murine macrophage cell line P388D1. The purification of PCT-GF was accomplished by a
Adriana Catalli et al.
PloS one, 9(5), e96891-e96891 (2014-05-14)
Despite the fact that glucocorticoids and long acting beta agonists are effective treatments for asthma, their effects on human mast cells (MC) appear to be modest. Although MC are one of the major effector cells in the underlying inflammatory reactions
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