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Merck
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Key Documents

HPA027011

Sigma-Aldrich

Anti-SLC35C2 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-C20orf5, Anti-CGI-15, Anti-OVCOV1, Anti-bA394O2.1

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About This Item

分類程式碼代碼:
12352203
人類蛋白質圖譜編號:
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

產品線

Prestige Antibodies® Powered by Atlas Antibodies

形狀

buffered aqueous glycerol solution

物種活性

human

技術

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

免疫原序列

KALHSRGDGGPKALKGLGSSPDLELLLRSSQREEGDNEEEEYFVAQ

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SLC35C2(51006)

一般說明

Solute carrier family 35 member C2 (SLC35C2) is a nucleotide sugar transporter, which belongs to solute carriers 35 family. It has multiple transmembrane helices and is present on Golgi and endoplasmic reticulum membranes. SLC35C2 is also called OVCOV1 and is mapped to human chromosome 20q13.12. It exists in two isoforms and is majorly expressed in reproductive tissues.

免疫原

solute carrier family 35 (GDP-fucose transporter), member C2

應用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生化/生理作用

Solute carrier family 35 member C2 (SLC35C2) functions to transport sugars from cytosol to organelles. It mediates the transport of guanosine diphosphate (GDP)-fucose and aids fucosylation of epidermal growth factor-like (EGF) repeats in the notch receptors. It also favors notch signalling.

特點和優勢

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

聯結

Corresponding Antigen APREST73208

外觀

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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访问文档库

Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells
Lu L, et al.
The Journal of Biological Chemistry, 36245?36254-36245?36254 (2010)
Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics
Gamwell L, et al.
Orphanet Journal of Rare Diseases, 8(1), 33-33 (2013)
Identification, molecular characterization, and tissue expression of OVCOV1
Leach R, et al
Mammalian Genome, 13(11), 619-624 (2002)
Roles of the nucleotide sugar transporters (SLC35 family) in health and disease
Song Z
Molecular Aspects of Medicine, 34(2-3), 590-600 (2013)
Assignment1 of OVCOV1 (alias CGI-15) to human chromosome 20 band q13. 1? q13. 2 by fluorescent in situ hybridization
Leach R, et al.
Cytogenetic and genome research, 94(3-4), 252-253 (2001)

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