HPA026763
Anti-NENF antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-Cell immortalization-related protein 2, Anti-Neudesin, Anti-Neuron-derived neurotrophic factor, Anti-SPUF protein, Anti-Secreted protein of unknown function
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所有图片(2)
About This Item
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:20-1:50
免疫原序列
RLFTEEELARYGGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAKMS
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NENF(29937)
一般說明
Neuron derived neurotrophic factor (NENF), also called as neudesin and GIG47, is mapped to human chromosome 1p33. This gene is expressed only in vertebrates. NENF codes for a novel secretory protein with 172 amino acids named neudesin. Primary structure of this protein might contain cytochrome b5-like heme/steroid-binding domain. In mouse, neudesin is expressed in heart, kidney, brain, and lung.
免疫原
Neudesin Precursor recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
Neuron derived neurotrophic factor (NENF) or GIG47 as an oncogene plays a crucial role in human tumorigenesis. It is highly expressed in various human cancer tissues, such as uterine cervix cancer, lymphoma, colon, lung, skin, leukemia and even breast cancer. Neudesin acts as a neurotrophic factor in neurons and undifferentiated neural cells. The neurotrophic property of this protein is transmitted by the activation of mitogen-activated protein (MAP) and phosphatidylinositol 3-kinase (PI-3K) pathways. NENF or neudesin is a primary extracellular heme-binding protein implicated in intercellular signal transduction. In mouse, neudesin plays a vital role in neural cell proliferation and neuronal differentiation.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST76694
外觀
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells.
Kimura I
Journal of Neuroscience Research, 83(8), 1415-1424 (2006)
Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain.
Kimura I
The Journal of Biological Chemistry, 283(7), 4323-4331 (2008)
The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis.
The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis.
The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis.
Han KH
BMC Cancer, 12:274 (2012)
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