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Merck
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Key Documents

HPA024467

Sigma-Aldrich

Anti-WIPF2 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab3

别名:

Anti-WAS/WASL-interacting protein family member 2, Anti-WASP-interacting protein-related protein, Anti-WIP- and CR16-homologous protein, Anti-WIP-related protein

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About This Item

分類程式碼代碼:
12352203
人類蛋白質圖譜編號:
HPA024467

生物源

rabbit

品質等級

100

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

產品線

Prestige Antibodies® Powered by Atlas Antibodies

形狀

buffered aqueous glycerol solution

物種活性

mouse, human, rat

加強驗證

orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation

技術

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200

免疫原序列

PPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQ

UniProt登錄號

Q8TF74

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... WIPF2(147179)

相关类别

一般說明

WIPF2 (WAS/WASL interacting protein family, member 2)/WICH (WIP- and CR16-homologous protein)/ WIRE (another N-WASP-binding member of the family) is a member of the Wiskott-Aldrich syndrome proteins (WASP) family. It has a verprolin homology domain. This gene located on human chromosome 17q21.

免疫原

WAS/WASL-interacting protein family member 2 recombinant protein epitope signature tag (PrEST)

應用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-WIPF2 antibody has been used in immunofluorescence and immunoblot analysis.

生化／生理作用

WIPF2 (WAS/WASL interacting protein family, member 2)/WICH (WIP- and CR16-homologous protein)/ WIRE (another N-WASP-binding member of the family) participates in actin-microspike formation. It modulates the generation of invadopodium and maturation in human breast cancer cell invasion. This protein plays an important role in matrix degradation and cell migration in diverse matrices. WIPF2 is also involved in the assembly of the actin cytoskeleton, mediated by WASP.

特點和優勢

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

聯結

Corresponding Antigen APREST75846

外觀

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.
Van Itallie CM, et al.
Molecular Biology of the Cell, 26(15), 2769-2787 (2015)
Esther García et al.
Scientific reports, 6, 23590-23590 (2016-03-25)
Cancer cells form actin-rich degradative protrusions (invasive pseudopods and invadopodia), which allows their efficient dispersal during metastasis. Using biochemical and advanced imaging approaches, we demonstrate that the N-WASP-interactors WIP and WICH/WIRE play non-redundant roles in cancer cell invasion. WIP interacts
Selwin K Wu et al.
Cell cycle (Georgetown, Tex.), 14(3), 315-322 (2015-01-16)
Cellular contractility regulates tissue cohesion and morphogenesis. In epithelia, E-cadherin adhesion couples the contractile cortices of neighboring cells together to produce tension at junctions that can be transmitted across the epithelium in a planar fashion. We have recently demonstrated that
WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation.
Kato M, et al.
Biochemical and Biophysical Research Communications, 291(1), 7-41 (2002)
High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion.
Lehtinen L, et al.
Oncotarget, 4(1), 48?63-48?63 (2013)
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