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产品名称
Anti-Huntingtin (N-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~110 kDa
物種活性
mouse, human, rat
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1.5 mg/mL
技術
western blot: 0.5-1.0 μg/mL using a HEK-293T cell lysate expressing a N-terminal fragment of human huntingtin
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HTT(3064)
mouse ... Htt(15194)
rat ... Htt(29424)
一般說明
Anti-Huntingtin (N-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human huntingtin, conjugated to KLH.
應用
Anti-Huntingtin (N-terminal) antibody has been used:
- in magnetic bead-assisted immunopurification
- in western blotting
- in immunofluorescent staining
- in immunoblotting
生化／生理作用
Huntingtin (Htt) is essential for embryonic development and neurogenesis. Htt associates with various cell organelles like the nucleus, endoplasmic reticulum and Golgi complex. It is also found in neurites and synapses where it associates with vesicular structures and microtubules, suggesting that it may play a role in intracellular vesicular trafficking, calcium homeostasis, neuronal survival, morphogenesis and transcriptional regulation. Aberrant expansion of glutamine repeats (polyQ) in the N-terminal region of huntingtin (htt) causes Huntington′s disease (HD) which is an autosomal dominant neurodegenerative disorder.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Huntingtin-protein interactions and the pathogenesis of Huntington's disease
Li SH and Li XJ
Trends in Genetics, 20(3), 146-154 (2004)
Wojciech J Szlachcic et al.
Frontiers in molecular neuroscience, 10, 253-253 (2017-08-30)
Huntington disease (HD) is an incurable neurodegenerative disorder caused by expansion of CAG repeats in huntingtin (HTT) gene, resulting in expanded polyglutamine tract in HTT protein. Although, HD has its common onset in adulthood, subtle symptoms in patients may occur
Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation
Morozova O A, et al.
Febs Letters, 589(15), 1897-1903 (2015)
Luisa Massai et al.
BMC biochemistry, 14, 34-34 (2013-11-28)
Huntington's disease (HD) is a monogenic disorder caused by an aberrant expansion of CAG repeats in the huntingtin gene (HTT). Pathogenesis is associated with expression of the mutant (mHTT) protein in the CNS, with its levels most likely related to
Normal huntingtin function: an alternative approach to Huntington's disease
Cattaneo E, et al.
Nature Reviews. Neuroscience, 6(12), 919-919 (2005)
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