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H5784

Sigma-Aldrich

(2-羟丙基)-β-环糊精 溶液

别名:

Hydroxypropyl-β-cyclodextrin

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About This Item

线性分子式:
(C6H9O5)7 · (C3H7O)4.5
MDL號碼:
MFCD00069372
分類程式碼代碼:
12352201
PubChem物質ID:
24895710
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

200

形狀

solution (clear, colorless)

分子量

~1396 Da

濃度

45 % (w/v) in H2O

儲存溫度

2-8°C

SMILES 字串

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C105H196O56/c1-50(106)22-127-43-71-78-85(134-29-57(8)113)92(141-36-64(15)120)99(148-71)156-79-72(44-128-23-51(2)107)150-101(94(143-38-66(17)122)86(79)135-30-58(9)114)158-81-74(46-130-25-53(4)109)152-103(96(145-40-68(19)124)88(81)137-32-60(11)116)160-83-76(48-132-27-55(6)111)154-105(98(147-42-70(21)126)90(83)139-34-62(13)118)161-84-77(49-133-28-56(7)112)153-104(97(146-41-69(20)125)91(84)140-35-63(14)119)159-82-75(47-131-26-54(5)110)151-102(95(144-39-67(18)123)89(82)138-33-61(12)117)157-80-73(45-129-24-52(3)108)149-100(155-78)93(142-37-65(16)121)87(80)136-31-59(10)115/h50-126H,22-49H2,1-21H3

InChI 密鑰

DCQLZTSRKLWEAB-UHFFFAOYSA-N

一般說明

2-羟丙基-β-环糊精是通过对环低聚糖β-环糊精进行化学修饰而得到的。它被用作疫苗的潜在佐剂。水溶液缓冲液中的2-羟丙基-β-环糊精可增加药物的溶解度。它对小鼠和兔子无毒。药物/环糊精配合物的形成是一个快速可逆的反应，配合物以溶液和结晶两种状态存在。许多这类络合物的溶液可被冻干以产生可压缩成片剂的易溶性粉末。

應用

(2-羟丙基)-β-环糊精溶液已用于：
  • 制备Cdc42活性特异性抑制剂（CASIN）药物新鲜溶液，用于C57BL/6小鼠表观遗传衰老特征分析
  • 制备重塑素和重塑素荧光剂溶液，用于评估重塑素在小鼠体内的毒性
  • 作为柠檬酸钠溶液的组分，用于复溶卡非佐米（PR-171）

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Sun Kyung Kim et al.
Frontiers in immunology, 7, 435-435 (2016-11-05)
2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a chemically modified cyclic oligosaccharide produced from starch that is commonly used as an excipient. Although HP-β-CD has been suggested as a potential adjuvant for vaccines, its immunological properties and mechanism of action have yet to be
Min K Lee et al.
Pain, 139(2), 367-375 (2008-06-21)
This study provides the first demonstration that central cannabinoids modulate the antinociceptive actions of metabotropic glutamate receptors (mGluRs) on formalin-induced temporomandibular joint (TMJ) nociception. Noxious scratching behavior induced by formalin injection in the TMJ was used as a model of
Clemens Bönisch et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 27(1-2), 17-28 (2015-12-15)
Epigenetic inheritance (EI) of metabolic phenotypes via the paternal lineage has been shown in rodent models of diet-induced obesity (DIO). However, the factors involved in soma-to-germline information transfer remain elusive. Here, we address the role of alterations in insulin, leptin
Kristine O Vasquez et al.
The Journal of pharmacology and experimental therapeutics, 361(1), 87-98 (2017-01-25)
Hepatocellular and cholestatic forms of drug-induced liver injury (DILI) are major reasons for late-stage termination of small-molecule drug discovery research projects. Biochemical serum markers are limited in their ability to sensitively and specifically detect both of these common DILI forms
Elisabete F Carapuça et al.
The Journal of pathology, 239(3), 286-296 (2016-04-12)
Stromal targeting for pancreatic ductal adenocarcinoma (PDAC) is rapidly becoming an attractive option, due to the lack of efficacy of standard chemotherapy and increased knowledge about PDAC stroma. We postulated that the addition of stromal therapy may enhance the anti-tumour
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Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds in tissue culture, cell culture, or other water-based applications.

Cyclodextrins

Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds in tissue culture, cell culture, or other water-based applications.

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