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Merck

H5527

Sigma-Aldrich

潮霉素 B 溶液 来源于吸水链霉菌

≥60% (HPLC), 45-60 mg/mL in H2O, γ-irradiated

别名:

Hygromycin b, Hygrovetine

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About This Item

经验公式(希尔记法):
C20H37N3O13
CAS号:
分子量:
527.52
Beilstein:
6755837
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.85

生物源

Streptomyces hygroscopicus

品質等級

無菌

γ-irradiated

濃度

≥60% (HPLC)
45-60 mg/mL in H2O

顏色

yellow-brown to orange

抗生素活性譜

viruses

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1

InChI 密鑰

GRRNUXAQVGOGFE-XKIAHZFYSA-N

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一般說明

Chemical structure: aminoglycoside

應用

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

生化/生理作用

抗菌剂和抗真菌剂。作用方式:在原核生物和真核生物中,通过诱导 mRNA 模板的误读而抑制蛋白质合成。它可选择性透入因病毒感染而变得可渗透的细胞。

注意

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.

準備報告

This product is a solution that is =60% (HPAE), 45-60 mg/mL in H2O, and γ-irradiated .

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Dam. 1 - Resp. Sens. 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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