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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to tan
溶解度
DMSO: ≥12 mg/mL
儲存溫度
−20°C
SMILES 字串
Cl.C[C@@H]1NC(C)(C)CO[C@@]1(O)c2cccc(Cl)c2
InChI
1S/C13H18ClNO2.ClH/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10;/h4-7,9,15-16H,8H2,1-3H3;1H/t9-,13+;/m0./s1
InChI 密鑰
ORXTVTDGPVINDN-BTJVGWIPSA-N
一般說明
(2S,3S)-羟基安非他酮是安非他酮的主要代谢产物。
生化／生理作用
（2S，3S）-羟基安非他酮是多巴胺转运蛋白（DAT）和去甲肾上腺素转运蛋白（NET）转运蛋白抑制剂和烟碱型乙酰胆碱受体（nAChR）家族调节剂。 据报道，羟基安非他酮有助于抗抑郁和戒烟。(2S,3S)和(2R,3R)代谢产物均可逆转尼古丁依赖性小鼠的情感和躯体戒断症状，但(2S,3S)-羟基安非他酮更有效。(2S,3S)-羟基安非他酮可显著降低小鼠的尼古丁奖赏效应。
特點和優勢
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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商品
These distinct transporters, NET, DAT and SERT, respectively, are of particular clinical interest because they are the molecular targets for many antidepressants as well as drugs of abuse, such as cocaine and the amphetamines.
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