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Merck

H0540

Sigma-Aldrich

Anti-Hepatocyte Growth Factor antibody produced in goat

affinity isolated antibody, lyophilized powder

别名:

Anti-HGF

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About This Item

MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.41

生物源

goat

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

lyophilized powder

物種活性

mouse

技術

capture ELISA: 0.2-0.8 μg/mL
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL

UniProt登錄號

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

mouse ... Hgf(15234)

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免疫原

purified, NSO cell-derived recombinant mouse hepatocyte growth factor.

生化/生理作用

Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Shinya Mizuno et al.
Frontiers in bioscience : a journal and virtual library, 13, 7072-7086 (2008-05-30)
Hepatocyte growth factor (HGF) and Met/HGF receptor play roles in dynamic growth and morphogenesis during development and regeneration of organs, including the kidney. In the kidney, HGF targets different types of cells, while its biological actions depend on a target
Weon-Kyoo You et al.
BMB reports, 41(12), 833-839 (2009-01-07)
Angiogenesis in tumors is driven by multiple growth factors that activate receptor tyrosine kinases. An important driving force of angiogenesis in solid tumors is signaling through vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). Angiogenesis inhibitors that target this
K Matsumoto et al.
Critical reviews in oncogenesis, 3(1-2), 27-54 (1992-01-01)
Hepatocyte growth factor (HGF) is the most potent mitogen for mature hepatocytes and seems to act as a hepatotropic factor that has not been purified over the past 30 years. HGF was first purified from rat platelets in 1986. HGF
Toshikazu Nakamura et al.
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 86(6), 588-610 (2010-06-17)
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor
Rie Nakahira et al.
Biochemical and biophysical research communications, 341(4), 897-903 (2006-02-16)
The stomach is constantly exposed to mechanical and chemical stresses. Under persistent damages, epithelial cell proliferation is required to maintain mucosal integrity. Nevertheless, which ligand system(s) is physiologically involved in gastric defense remains unclear. Herein, we provide evidence that HGF

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