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生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
95% (SDS-PAGE)
形狀
frozen liquid
比活性
8.8 units/mg protein (as assayed by the spectrophotometric determination of NADPH oxidation coupled to the glutathione peroxidase activity of GST T1-1 on cumene hydroperoxide (1.5 mM) in the presence of reduced glutathione (1 mM) in 100 mM NaPO4 (pH 7.0) at room temperature.)
分子量
25 kDa
濃度
1.95 mg/mL
儲存溫度
−70°C
基因資訊
human ... GSTT1(2952)
一般說明
Glutathione S-transferase theta 1 (GSTT1) and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants.GSTT1 is an enzyme that in humans is encoded by the GSTT1 gene. The GSTT1 gene contains five exons and four introns and spans 8092bp on genomic DNA. It is mapped to human chromosome 22q11.23. This gene codes for a 240 amino acids, which is mainly expressed in human liver. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: α, κ, μ, ω, π, σ, θ and ζ.
生化／生理作用
Glutathione S-transferase theta 1 (GSTT1) is an enzyme that in humans is encoded by the GSTT1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Mutation in the gene might lead to the development of lung, head and neck cancer. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
儲存和穩定性
The enzyme should be used by the end-user customer within 1 year of receipt.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Wen Sun et al.
BMC ophthalmology, 15, 84-84 (2015-07-26)
Glutathione S transferase (GST) polymorphisms have been considered as risk factors for age-related cataracts, but the results remain controversial. In this study, we have performed a meta-analysis to evaluate the association between polymorphisms of GSTM1 and GSTT1 and cataract risk.
Ender Coskunpinar et al.
Asian Pacific journal of cancer prevention : APJCP, 15(5), 2319-2321 (2014-04-11)
Our aim was to determine GSTT1 expression levels in left colon tumors and paired normal tissue in order to identify specific alterations in GSTT1 mRNA levels. Alterations in GSTT1 expression in twenty-four left- sided colon tumors and paired cancer free
Bacterial glutathione S-transferases: what are they good for?
Vuilleumier, S, et al.
Journal of Bacteriology, 179, 1431-1431 (1997)
Alfredo Santovito et al.
Journal of biochemical and molecular toxicology, 29(5), 234-239 (2015-02-04)
Occupational exposure to anaesthetic gases is one of the major hazards to healthcare personnel. We evaluated the cytogenetic effects of chronic exposure to low concentrations of anaesthetic gases in operating theatres. The study included 21 anesthetists and 21 control subjects
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
Hayes, J. D, et al.
Free Radical Research, 31, 273-300 (1999)
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