推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 78 kDa
物種活性
mouse, hamster, human
加強驗證
independent
Learn more about Antibody Enhanced Validation
技術
immunocytochemistry: 1:1,000 using mouse fibroblasts NIH3T3 cells
microarray: suitable
western blot: 1:3,000 using human epitheloid carcinoma HeLa whole cell extract
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HSPA5(3309)
mouse ... Hspa5(14828)
一般說明
GRP78/BiP is a Ca2+-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.
應用
Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
生化／生理作用
GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca2+ ionophores, inhibition of the ER Ca2+ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca2+ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Mina Thon et al.
Scientific reports, 6, 34312-34312 (2016-09-30)
Leptin, an adipocyte-derived hormone, centrally regulates energy homeostasis. Overlaps in the regulation of glucose and energy homeostasis have been reported between leptin and insulin. However, the effects of insulin on leptin's actions in the central nervous system (CNS) have not
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease
Wang WX, et al.
The American Journal of Pathology, 177(1), 334-345 (2010)
GRP78 at the centre of the stage in cancer and neuroprotection
Casas, Caty
Frontiers in Neuroscience, 11, 177-177 (2017)
BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation
Brennan LA, et al.
Experimental Eye Research, 174, 173-184 (2018)
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress
Ouyang YB, et al.
Mitochondrion, 11(2), 279-286 (2011)
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