跳转至内容
Merck
所有图片(1)

Key Documents

View All Documentation

G2392

Sigma-Aldrich

Disialoganglioside GD1a from bovine brain

≥95% (TLC), lyophilized powder

别名:

Ganglioside GD1a, disialo from bovine brain

登录查看公司和协议定价
所有图片(1)

About This Item

CAS号:
12707-58-3
Beilstein:
6228822
MDL號碼:
MFCD00130960
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

200

化驗

≥95% (TLC)

形狀

lyophilized powder

溶解度

DMSO: soluble

儲存溫度

−20°C

InChI

1S/C86H152N4O39.2Na/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-51(100)50(90-60(105)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2)46-118-80-69(111)67(109)72(57(43-94)120-80)123-82-71(113)78(129-86(84(116)117)39-53(102)62(88-48(4)98)77(128-86)65(107)55(104)41-92)74(59(45-96)122-82)124-79-63(89-49(5)99)75(66(108)56(42-93)119-79)125-81-70(112)68(110)73(58(44-95)121-81)126-85(83(114)115)38-52(101)61(87-47(3)97)76(127-85)64(106)54(103)40-91;;/h34,36,50-59,61-82,91-96,100-104,106-113H,6-33,35,37-46H2,1-5H3,(H,87,97)(H,88,98)(H,89,99)(H,90,105)(H,114,115)(H,116,117);;/q;2*+1/p-2/b36-34+;;/t50-,51+,52?,53?,54-,55-,56?,57?,58?,59?,61+,62+,63?,64-,65-,66?,67?,68?,69?,70?,71?,72?,73?,74?,75?,76?,77?,78?,79?,80?,81?,82?,85?,86?;;/m0../s1

InChI 密鑰

CWLDKTAXQZEVQN-CUEXFKMESA-L

正在寻找类似产品? 访问 产品对比指南

Amino Acid Sequence

Cer-Glc-Gal(NeuAc)-GalNAc-Gal-NeuAc

一般說明

Gangliosides are in the neuronal cell membranes and endoplasmic reticulum. They consist of a sialylated polysaccharide chain linked via β-glycosidic linkage to ceramide. They are also located in body fluids and plasma. GD1a consists of a neutral tetrasaccharide core with one sialic acid on the internal galactose and another sialic acid on the non-reducing terminal galactose.

應用

Disialoganglioside GD1a from bovine brain has been used:
  • as a receptor for the detection of murine norovirus-1 (MNV-1) by RT-PCR
  • as a glycolipid to study the interaction between protein human endogenous retrovirus W family pHERV-W ENV and glycolipids by enzyme-linked immunosorbent assay (ELISA)
  • as a reference standard to analyze the ganglioside signatures of prostate cancer cells by high-performance liquid chromatography

生化／生理作用

Gangliosides are involved in cellular functions such as the differentiation of neurons, formation of axons, synapses, cell proliferation, differentiation, adhesion, and cell death. In addition, gangliosides form microdomains on the outer surface of the cell membranes that are involved in signal transduction and help in the formation of dendrites. Gangliosides act as Ca2+ binding co-factors during synaptic transmission.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Elena Del Favero et al.
Journal of neurochemistry, 116(5), 833-839 (2011-01-11)
It is well known that the curvature of ganglioside-containing nanoparticles strongly depends on their headgroup structure, as determined in aggregates with 'stationary' composition, that is, when the system finds its optimal structure at the moment of lipid dissolution in aqueous
Marc A Benson et al.
The Journal of biological chemistry, 286(39), 34015-34022 (2011-08-19)
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin are the causative agents of the paralytic diseases botulism and tetanus, respectively. The potency of the clostridial neurotoxins (CNTs) relies primarily on their highly specific binding to nerve terminals and cleavage of SNARE proteins.
Yukari Sekiguchi et al.
Journal of neurology, neurosurgery, and psychiatry, 83(1), 23-28 (2011-10-20)
Whether or not antiganglioside antibodies are related to axonal or demyelinating Guillain-Barré syndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted in Western and Asian countries. To clarify whether antiganglioside antibodies are associated with axonal
Laura Mauri et al.
Glycobiology, 22(3), 352-360 (2011-09-17)
It is now emerging the new concept that the antibodies from some patients with Guillain-Barré syndrome (GBS) recognize an antigenic epitope formed by two different gangliosides, a ganglioside complex (GSC). We prepared the dimeric GM1-GD1a hybrid ganglioside derivative that contains
Induction of neuron-like tubes and liposome networks by cooperative effect of gangliosides and phospholipids
Kazunari A, et al.
Febs Letters, 534(1-2) (2002)
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门