所有图片(1)
About This Item
经验公式（希尔记法）:
C28H49N11O11
CAS号:
分子量:
715.76
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.32
推荐产品
生物源
human
品質等級
化驗
≥97% (HPLC)
形狀
powder
技術
blocking: suitable
ligand binding assay: suitable
儲存溫度
−20°C
SMILES 字串
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O
InChI
1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1
InChI 密鑰
ZRVZOBGMZWVJOS-VMXHOPILSA-N
基因資訊
human ... ITGA2B(3674) , ITGAV(3685)
正在寻找类似产品? 访问 产品对比指南
Amino Acid Sequence
Gly-Arg-Gly-Asp-Ser-Pro-Lys
一般說明
Gly-Arg-Gly-Asp-Ser-Pro-Lys是一种RGD肽。作为胞外基质(ECM)蛋白中的天然RGD肽，参与促进整合素介导的细胞与基质蛋白的黏附。RGD肽在细胞黏附蛋白（如纤连蛋白和玻连蛋白）中以重复形式存在。这种三肽被细胞中特定的整合素（如β1、β3和β5亚基）识别，存在于细胞表面，通过粘着斑(FA)复合物与肌动蛋白丝关联。
應用
Gly-Arg-Gly-Asp-Ser-Pro-Lys（RGD肽）已用于
- 作为抑制肽抑制整合素和纤连蛋白的结合
- 通过猪滋养外胚层粘附实验研究TGFβ（转化生长因子）对细胞粘附的影响
- 培养MC3T3-E1成骨细胞，通过AFM（原子力显微镜）检测其对细胞粘附的影响作用
- 制备RGD.Flt23k.NR纳米颗粒
- 确定RGD-整合素连接在细胞粘附过程中的参与
生化／生理作用
结合整合素的纤连蛋白类似物。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Yang Kyung Cho et al.
Investigative ophthalmology & visual science, 53(4), 2328-2336 (2012-03-20)
To determine if nanoparticles delivering plasmids expressing Flt23k (an anti-VEGF intraceptor) can enhance murine cornea transplant survival and whether their effect is synergistic with steroid therapy. Biodegradable PLGA Flt23k loaded or blank nanoparticles were prepared using the emulsion solvent evaporation
Kazuyuki Onodera et al.
European journal of cell biology, 84(1), 45-58 (2005-02-24)
Biomechanical forces are major epigenetic factors that determine the form and differentiation of skeletal tissues, and may be transduced through cell adhesion to the intracellular biochemical signaling pathway. To test the hypothesis that stepwise stretching is translated to molecular signals
Lily Y Koo et al.
Journal of cell science, 115(Pt 7), 1423-1433 (2002-03-16)
Integrin-mediated cell adhesion is central to cell survival, differentiation and motility. Many cell responses induced by integrins require both receptor occupancy and receptor aggregation, and appear to be regulated by both biochemical and biophysical means. Multidomain extracellular matrix molecules may
G A Gronowicz et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 9(2), 193-201 (1994-02-01)
The role of integrins, cell surface receptors involved in cell adhesion to the matrix, was studied in a mineralizing organ culture system. Integrin-mediated cell attachment to matrix proteins has been shown to depend partially on the amino acid sequence Arg-Gly-Asp
J Holland et al.
Biomaterials, 17(22), 2147-2156 (1996-11-01)
A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门