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Key Documents

G1049

Sigma-Aldrich

聚-L-γ-谷氨酸 钠盐

suitable for drug transporter assays, Mol wt ≥750,000

别名:

γ-PGA

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About This Item

分類程式碼代碼:
12352209
NACRES:
NA.26

product name

聚-L-γ-谷氨酸 钠盐,

形狀

powder

品質等級

分子量

≥750,000

技術

drug transporter assay: suitable

顏色

white to off-white

應用

cell analysis

儲存溫度

−20°C

應用

高分子量聚-γ-谷氨酸(γPGA)被证明可以在C57BL/6小鼠中增加NK细胞介导的细胞毒性水平以及 INF-γ分泌。 已经评估了可生物降解的γ-PGA纳米颗粒作为抗原递送载体 以及递送流感病毒血凝素(HA)疫苗的应用。 γ-PGA的其他生命科学应用包括用于可生物降解的纤维和纳米纤维片、水凝胶和冷冻保护剂。

其他說明

高分子量聚-γ-谷氨酸是一种谷氨酸聚合物,由α-氨基和γ-羧基之间的酰胺键连接。 γ-PGA是由芽孢杆菌发酵产生的。该亚基主要是L-异构体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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I L Shih et al.
Bioresource technology, 79(3), 207-225 (2001-08-14)
This review article deals with the chemistry and biosynthesis of poly-(gamma-glutamic acid) (gamma-PGA) produced by various strains of Bacillus. Potential applications of gamma-PGA as thickener, cryoprotectant, humectant, drug carrier, biological adhesive, flocculant, or heavy metal absorbent, etc. with biodegradability in
Tae Woo Kim et al.
Journal of immunology (Baltimore, Md. : 1950), 179(2), 775-780 (2007-07-10)
We analyzed the in vivo tumor regression activity of high molecular mass poly-gamma-glutamate (gamma-PGA) from Bacillus subtilis sups. chungkookjang. C57BL/6 mice were orally administered 10-, 100-, or 2000-kDa gamma-PGA or beta-glucan (positive control), and antitumor immunity was examined. Our results
Haryoung Poo et al.
Chemistry & biodiversity, 7(6), 1555-1562 (2010-06-22)
Ultra-high-molecular-weight poly-gamma-glutamic acid (gamma-PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of gamma-PGA are that it is water soluble, anionic, biodegradable, and edible. Development of gamma-PGA has pursued in terms of cosmetics/skin
Ilaria Massaiu et al.
Microbial cell factories, 18(1), 3-3 (2019-01-11)
Genome-scale metabolic models (GEMs) allow predicting metabolic phenotypes from limited data on uptake and secretion fluxes by defining the space of all the feasible solutions and excluding physio-chemically and biologically unfeasible behaviors. The integration of additional biological information in genome-scale models
Shigefumi Okamoto et al.
Vaccine, 27(42), 5896-5905 (2009-08-04)
Adding poly(gamma-glutamic acid) nano-particles (gamma-PGA-NPs), a safe, natural material, to subcutaneous immunization with influenza virus hemagglutinin (HA) vaccine increases the protective immune responses against influenza virus in mice. Here, we examined whether intranasal administration of the HA vaccine with gamma-PGA-NPs

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