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Merck
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Key Documents

EMU023091

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Rnaseh1

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About This Item

分類程式碼代碼:
41105324
NACRES:
NA.51

描述

Powered by Eupheria Biotech

品質等級

100

產品線

MISSION®

形狀

lyophilized powder

esiRNA cDNA 標靶序列

CAAGGCTCAGAACATCAGCAAGCTGGTTCTGTACACAGACAGCATGTTCACCATCAATGGGATAACTAACTGGGTTCAGGGCTGGAAGAAGAATGGCTGGAGAACAAGTACAGGGAAAGATGTGATCAACAAGGAGGACTTCATGGAGCTGGACGAGCTCACTCAGGGCATGGACATCCAGTGGATGCACATTCCTGGTCACTCAGGATTTGTGGGCAATGAAGAGGCCGACAGACTGGCACGGGAAGGAGCGAAGCAGTCTGAGGACTGAGCAGAGGAGCTGCTGCCGACTCAGACCCAAGGCAGAGGCTGTTTCTTTACCCTGCCGTGCACTGAGCTGTGCATGGAGGACACAGTGTAACCTGTGGCACAGCTTGGTGAGACGTGCTTACATAATGGAAAGGAAGTGTTAAATCCTGCTTTTGTGAGATTTCAGGGTCTGTCCCAA

Ensembl | 小鼠類登錄號

ENSMUSG00000020630

NCBI登錄號

NM_011275

運輸包裝

ambient

儲存溫度

−20°C

基因資訊

mouse ... RNASEH1(19819) , Rnaseh1(19819)

相关类别

一般說明

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

法律資訊

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Shin-Ichiro Hori et al.
Biochemical and biophysical research communications, 464(2), 506-511 (2015-07-15)
Antisense oligonucleotides (ASOs) can suppress the expression of a target gene by cleaving pre-mRNA and/or mature mRNA via RNase H1. Following the initial endonucleolytic cleavage by RNase H1, the target RNAs are degraded by a mechanism that is poorly understood.
Matthias Groh et al.
PLoS genetics, 10(5), e1004318-e1004318 (2014-05-03)
Friedreich ataxia (FRDA) and Fragile X syndrome (FXS) are among 40 diseases associated with expansion of repeated sequences (TREDs). Although their molecular pathology is not well understood, formation of repressive chromatin and unusual DNA structures over repeat regions were proposed

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