生物源
mouse
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
E-257, monoclonal
形狀
buffered aqueous solution
物種活性
Drosophila
濃度
~1.5 mg/mL
技術
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: 0.25-0.5 μg/mL using recombinant cytoplasmic domain fragment of the Drosophila EGFR (amino acids 1200-1267)
同型
IgG1
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
Drosophila melanogaster ... Egfr(37455)
一般說明
The signalling by dEGFR (also known as Torpedo or DER) is crucial for the development processes in Drosophila. The dEGFR signalling results in the activation of the canonical RAS/RAF/MEK/MAPK cascade. A variety of modulators such as Gro, TGF-α, Argos, Sprouty and Notch play an integrative role in EGFR signalling. The other pathways EGFR is involved in the development of the compound eye, larval, eye, wing and malphigian tubule development. Monoclonal Anti-dEGFR, Cytoplasmic Domain recognizes Drosophila Epidermal Growth Factor Receptor (EGFR). The antibody epitope resides within amino acids 1200-1267 of Drosophila EGFR.
免疫原
recombinant cytoplasmic domain fragment of the Drosophila EGFR (amino acids 1200-1267).
應用
Anti-dEGF Receptor, Cytoplasmic Domain antibody may be used for immunoblotting at a working concentration of 0.25-0.5 μg/ml. The antibody is suitable for immunohistochemistry and ELISA.
外觀
Solution in 0.01 M phosphate buffered saline containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Richard W Carthew
Current opinion in genetics & development, 17(4), 309-313 (2007-07-10)
The insect compound eye is one of the most precise and highly ordered patterns in the living world. It develops from an unpatterned simple epithelium by a series of cell fate decisions and complex morphogenetic movements. In the first days
P Hasson et al.
British journal of cancer, 94(6), 771-775 (2006-03-02)
In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In
Andrew Tomlinson et al.
Developmental biology, 454(2), 181-189 (2019-06-18)
Sevenless (Sev) is a Receptor Tyrosine Kinase (RTK) that is required for the specification of the Drosophila R7 photoreceptor. Other Drosophila photoreceptors are specified by the action of another RTK; the Drosophila EGF Receptor (DER). Why Sev is required specifically
Ben-Zion Shilo
Development (Cambridge, England), 132(18), 4017-4027 (2005-08-27)
The epidermal growth factor receptor (EGFR) signaling cascade represents one of the cardinal pathways that transmits information between cells during development in a broad range of multicellular organisms. Most of the elements that constitute the core EGFR signaling module, as
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