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E2127

Sigma-Aldrich

β-雌二醇3-(β-D-葡萄糖醛酸) 钠盐

别名:

1,3,5(10)-Estratriene-3,17β-diol 3-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-glucuronide

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About This Item

线性分子式:
C24H31O8Na
CAS号:
14982-12-8
分子量:
470.49
MDL號碼:
MFCD00056552
分類程式碼代碼:
51111800
PubChem物質ID:
24894454
NACRES:
NA.77

無菌

non-sterile

化驗

≥98% (HPLC)

形狀

powder

溶解度

water: 10 mg/mL, clear to slightly hazy

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

[Na].CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(O)=O)ccc34)C1CCC2O

InChI

1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;

InChI 密鑰

JKYLXXZHJUQLMK-UHFFFAOYSA-N

應用

β-Estradiol 3-(β-D-glucuronide) sodium salt has been used in estrogen administration. It has also been used to determine the amount of two types of glucuronidated estradiols such as estradiol-3- α glucuronide and estradiol-17- β glucuronide.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302 + H312 + H332

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Mohamed-Eslam F Mohamed et al.
Xenobiotica; the fate of foreign compounds in biological systems, 40(10), 663-669 (2010-07-30)
Commonly used herbal supplements were screened for their potential to inhibit UGT1A1 activity using human liver microsomes. Extracts screened included ginseng, echinacea, black cohosh, milk thistle, garlic, valerian, saw palmetto, and green tea epigallocatechin gallate (EGCG). Estradiol-3-O-glucuronide (E-3-G) formation was
K S Kan et al.
The Biochemical journal, 261(1), 297-300 (1989-07-01)
By using rat liver perfusion under one-pass conditions with a single pulse of horseradish peroxidase (HRP), the biliary output of HRP was used as an indicator of paracellular permeability change caused by the cholestatic compound oestradiol 17 beta-glucuronide (E17G). Since
N Kanai et al.
The American journal of physiology, 270(2 Pt 2), F326-F331 (1996-02-01)
Although substantial evidence indicates that estradiol-17 beta (E2) is conjugated to the glucuronide in the kidney and then excreted by a direct tubular secretory route and that the liver transports E2 glucuronides via carrier-mediated mechanisms, the transporters involved in these
M H Rae et al.
Clinica chimica acta; international journal of clinical chemistry, 176(1), 71-81 (1988-08-15)
Urinary oestrone-3-glucuronide, oestradiol-3-glucuronide, oestrone and oestradiol were measured by radioimmunoassay methods adapted for the very low levels found in postmenopausal women. Oestrogen concentrations related to creatinine in morning urine samples from ten postmenopausal women were found to correlate well with
[Contraception per computer. Hormone system persona--results of studies in Germany].
G Freundl et al.
Fortschritte der Medizin, 116(9), 47-48 (1998-05-13)
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