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Merck

E0377

Sigma-Aldrich

D-赤藓糖-4-磷酸酯 钠盐

≥50% (TLC)

别名:

4-磷酸-D-赤藓糖 钠盐

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About This Item

经验公式(希尔记法):
C4H8NaO7P
分子量:
222.07
分類程式碼代碼:
12352201
NACRES:
NA.25

品質等級

化驗

≥50% (TLC)

形狀

powder

顏色

white to off-white

溶解度

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

儲存溫度

−20°C

SMILES 字串

[Na+].[H]C(=O)[C@H](O)[C@H](O)COP(O)([O-])=O

InChI

1S/C4H9O7P.Na/c5-1-3(6)4(7)2-11-12(8,9)10;/h1,3-4,6-7H,2H2,(H2,8,9,10);/q;+1/p-1/t3-,4+;/m0./s1

InChI 密鑰

KKDBADMPNGAKHM-RFKZQXLXSA-M

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應用

D-赤藓糖-4-磷酸(E4P)可作为底物,用于识别、区分和鉴定2-酮基-3-脱氧-6-磷酸半乳糖酸(KDPGal)醛缩酶和3-脱氧-D-阿拉伯-庚酮酸7-磷酸(DAH7P)合成酶,这两种酶用于启动微生物和植物中的莽草酸途径。可作为底物识别、区分和鉴定甘油醛-3-磷酸脱氢酶(GAPDH),这种酶参与致病微生物的表面抗原和毒力因子形成。 PLP(吡哆醛5′-磷酸)合成酶复合物负责从头合成恶性疟原虫中的维生素B6,在疟疾研究中,E4P可作为该复合物PfPdx1组分的抑制剂。

生化/生理作用

D-赤藓糖-4-磷酸作为中间产物参与磷酸戊糖途径,以及苯丙氨酸、酪氨酸、色氨酸生物合成与维生素B6代谢。

其他說明

为了全面了解我们针对客户研究提供的各种单糖产品,建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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Darmawi Juminaga et al.
Applied and environmental microbiology, 78(1), 89-98 (2011-10-25)
Efficient biosynthesis of L-tyrosine from glucose is necessary to make biological production economically viable. To this end, we designed and constructed a modular biosynthetic pathway for L-tyrosine production in E. coli MG1655 by encoding the enzymes for converting erythrose-4-phosphate (E4P)
Bianca Derrer et al.
Frontiers in bioscience (Landmark edition), 18, 944-969 (2013-06-12)
The shikimate pathway provides basic building blocks for a variety of aromatic compounds including aromatic amino acids, ubiquinone, folate and compounds of the secondary metabolism. The seven enzymatic reactions of the pathway lead to the generation of chorismate from simple
Shaun B Reeksting et al.
The Biochemical journal, 449(1), 175-187 (2012-10-09)
Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum. This parasite synthesizes vitamin B6 de novo via the PLP (pyridoxal 5'-phosphate) synthase enzymatic complex consisting of PfPdx1 and PfPdx2 proteins. Biosynthesis of PLP is largely performed by PfPdx1
Scott R Walker et al.
Bioorganic & medicinal chemistry letters, 21(17), 5092-5097 (2011-04-16)
3-Deoxy-d-arabino-heptulosonate 7-phosphate (DAH7P) synthase catalyses the first step of the shikimate pathway for the biosynthesis of aromatic compounds. Enzymes of this pathway have been identified as potential targets for drug design. The reaction catalysed by DAH7P synthase is an aldol
Ningqing Ran et al.
Journal of the American Chemical Society, 129(19), 6130-6139 (2007-04-25)
Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) aldolase for microbial synthesis of shikimate pathway products provides an alternate strategy to circumvent the competition for phosphoenolpyruvate between 3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP) synthase and the phosphoenolpyruvate:carbohydrate phosphotransferase system in Escherichia coli. E. coli KDPGal

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