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Merck

D9761

Sigma-Aldrich

6-脱氧-D-葡萄糖

别名:

D-异鼠李糖, Epifucose, Quinovose

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About This Item

经验公式(希尔记法):
C6H12O5
CAS号:
分子量:
164.16
Beilstein:
1723317
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.52

等級

Molecular Biology
for molecular biology

品質等級

化驗

≥98% (TLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

C[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3-,4+,5-,6?/m1/s1

InChI 密鑰

SHZGCJCMOBCMKK-GASJEMHNSA-N

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一般說明

6-脱氧-D-葡萄糖是D-葡萄糖(右旋葡萄糖)的一种结构同源物和稳定的类似物。它在碳6位上缺少羟基。它也是甘露糖的类似物。

應用

6-脱氧-D-葡萄糖已被用作圆二色性测量中的标准品。它也作为糖用于孵育经饥饿处理的双歧杆菌HMX44A.atg1-1细胞,从而用于显微镜研究。

生化/生理作用

2-脱氧-D-葡萄糖(2-DG)在研究葡萄糖的生物学功能中可用作糖酵解抑制剂。它不可被代谢,会引发内质网的应激,因而可阻止癌细胞中碳水化合物的代谢。它具有靶向抗化学性缺氧癌细胞的治疗潜力。2-DG可通过取代甘露糖终止 N-连接糖基化。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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D Granot et al.
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Journal of bacteriology, 152(3), 1295-1297 (1982-12-01)
6-Deoxy-D-glucose, a structural homomorph of D-glucose which lacks a hydroxyl group at carbon 6 and thus cannot be phosphorylated, is transported by Saccharomyces cerevisiae via a facilitated diffusion system with affinity equivalent to that shown with D-glucose. This finding supports
C Laporte et al.
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A J Fry et al.
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Kinetic parameters for entry of D-fructose into Trypanosoma brucei brucei have been determined. The net uptake of D-fructose was found to be rapid and occurred at a rate which was comparable with that observed for uptake of D-glucose. The Km

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