跳转至内容
Merck
所有图片(2)

主要文件

查看所有文档

D7006

Sigma-Aldrich

二氢叶酸

≥90%

别名:

7,8-二氢蝶酰- L -谷氨酸, FAH2, 二氢蝶酰- L -谷氨酸

登录查看公司和协议定价
所有图片(2)

About This Item

经验公式（希尔记法）:
C19H21N7O6
CAS号:
4033-27-6
分子量:
443.41
Beilstein:
69017
MDL號碼:
MFCD00083619
分類程式碼代碼:
12352106
PubChem物質ID:
24894068
NACRES:
NA.79

生物源

synthetic (organic)

品質等級

200

化驗

≥90%

形狀

powder

顏色

light yellow to dark yellow-orange

儲存溫度

−20°C

SMILES 字串

NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1

InChI

1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1

InChI 密鑰

OZRNSSUDZOLUSN-LBPRGKRZSA-N

基因資訊

human ... DHFRP1(573971)
mouse ... Dhfr(13361)

正在寻找类似产品? 访问 产品对比指南

相关类别

一般說明

通过二氢叶酸还原酶 (DHFR) 将膳食叶酸转化为四氢叶酸的中间产物。在细菌中，二氢叶酸是 7,8-二氢蝶酸由二氢叶酸合成酶生成。

應用

二氢叶酸用于心肌黄酶偶联测定，测定二氢叶酸还原酶（DHFR）活性。它也用作测定缓冲液成分，确定二氢叶酸还原酶（DHFR）的活性。

生化／生理作用

叶酸 (FA) 和二氢叶酸 (FAH2) 是二氢叶酸还原酶 (s) 的底物，将其还原成四氢叶酸 (THF)，后者支持“一碳”转移。嘌呤、胸苷酸和各种氨基酸的从头合成以及翻译后甲基化（表观遗传学）需要四氢叶酸。

包裝

密封安瓿。

相關產品

产品编号
说明
价格

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
SLCJ6914
SLCG1126
SLCB3542
SLBX2640
SLBS6938

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

其他客户在看

Slide 1 of 5

1 of 5

亚叶酸钙 European Pharmacopoeia (EP) Reference Standard

C0250000

亚叶酸钙

7,8-Dihydro-L-biopterin ≥94% (HPLC)

Sigma-Aldrich

37272

7,8-Dihydro-L-biopterin

2-乙基吡啶 97%

Sigma-Aldrich

112429

2-乙基吡啶

NADPH powder, =97% (dry weight)

Roche

NADPH-RO

NADPH

vibrant-m

Y0000664

甲氨蝶呤杂质E

Tobias Sahr et al.
The Biochemical journal, 396(1), 157-162 (2006-02-10)
pABA (p-aminobenzoate) is a precursor of folates and, besides esterification to glucose, has no other known metabolic fate in plants. It is synthesized in two steps from chorismate and glutamine, the first step being their conversion into glutamate and ADC
Karunesh Arora et al.
Journal of the American Chemical Society, 131(15), 5642-5647 (2009-03-28)
Conformational changes in enzymes are well recognized to play an important role in the organization of the reactive groups for efficient catalysis. This study reveals atomic and energetic details of the conformational change process that precedes the catalytic reaction of
Nina M Antikainen et al.
Biochemistry, 44(51), 16835-16843 (2005-12-21)
Ensemble kinetics and single-molecule fluorescence microscopy were used to study conformational transitions associated with enzyme catalysis by dihydrofolate reductase (DHFR). The active site loop of DHFR was labeled with a fluorescence quencher, QSY35, at amino acid position 17, and the
T Yoshikawa et al.
Biotechnology and bioengineering, 74(5), 435-442 (2001-06-28)
In previous work, we clarified the relationship between the productivity and stability of gene-amplified cells and the location of the amplified gene. The location of the amplified gene enabled us to classify resistant cells into two types. One type of
T Yoshikawa et al.
Biotechnology progress, 16(5), 710-715 (2000-10-12)
Previously, we established an easy and quick construction method for obtaining a stable and highly productive gene-amplified recombinant Chinese hamster ovary (CHO) cell line. With a gradual increase in methotrexate (MTX) concentration, gene-amplified cell pools had high and stable specific
查看所有相关文献

商品

Folic Acid Metabolism in Cancer

This issue of Biofiles reviews some of our newest and most innovative technologies and their specific applications toward cancer research. In preparing this issue of Biofiles, one is reminded how complex the disease of cancer is, and how difficult it is to identify one topic that is completely unrelated to any other.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门