D6140

地美环素 盐酸盐

powder or crystals, suitable for cell culture

• 别名: 7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride
• 经验公式（希尔记法）: C₂₁H₂₁ClN₂O₈ · HCl
• CAS号: 64-73-3
• 分子量: 501.31
• Beilstein: 3849198
• EC號碼: 200-592-2
• MDL號碼: MFCD00082371
• 分類程式碼代碼: 12352207
• PubChem物質ID: 24278380
• NACRES: NA.75

属性

• product name: 地美环素 盐酸盐, powder or crystals
• 化驗: 89.5-102.0% anhydrous basis
• 形狀: powder or crystals
• 技術: cell culture | mammalian: suitable
• 溶解度: soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C
• SMILES 字串: Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O
• InChI: 1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
• InChI 密鑰: GVSJQNRGSCOSNJ-KBHRXELFSA-N

说明

一般說明

Chemical structure: tetracycline

生化／生理作用

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.

Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Warning
• 危險聲明: H302 + H312 + H332,H315,H319,H335,H341
• 防範說明: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves