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生物源
synthetic (organic)
品質等級
化驗
≥98% (HPLC)
形狀
solid
mp
107-109 °C
溶解度
DMSO: 1 mg/mL, clear, colorless to faintly yellow
儲存溫度
2-8°C
InChI
1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChI 密鑰
RVOUDNBEIXGHJY-UHFFFAOYSA-N
應用
在体内研究中，DPQ已被用作一种PARP 1（聚(ADP-核糖)聚合酶1）抑制剂，用于确定辐照后γ-H2AX（H2A组蛋白家族成员X）的损失。
生化／生理作用
在局部缺血的影响下，已知3,4-二氢-5-[4-(1-哌啶基)丁氧基]-1(2H)-异喹啉酮（DPQ）可降低PARP 1（聚(ADP-核糖)聚合酶1）介导的细胞凋亡。它被认为是比传统使用的PARP1抑制剂3-氨基苯甲酰胺更有效的抑制剂。
DPQ是一种非常有效的聚(ADP-核糖)聚合酶（PARP）抑制剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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