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D4626

Sigma-Aldrich

葡聚糖 来源于肠系膜明串珠菌

average mol wt 15,000-30,000

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About This Item

线性分子式:
(C6H10O5)n
CAS号:
9004-54-0
EC號碼:
232-677-5
MDL號碼:
MFCD00130935
分類程式碼代碼:
12352201
NACRES:
NA.25

生物源

bacterial (Leuconostoc mesenteroides)

品質等級

200

形狀

powder

光學活性

[α]/D 199°

分子量

average mol wt 15,000-30,000

顏色

white

溶解度

water: 20 mg/mL, clear, colorless to faintly yellow

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

InChI 密鑰

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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相关类别

一般說明

葡聚糖是由线性α(1→6)连接的葡萄糖单元和α (1→3)连接的支链组成的支链葡聚糖。葡聚糖的分子量范围为10,000至150,000 kDa。

應用

葡聚糖在许多应用中被用作体积增量剂、渗透压调节剂、稳定剂、基质组分、共聚物、微载体、粘合剂、粘度调节剂、抗血栓药、润滑剂和物理结构组分。葡聚糖可用作长亲水间隔臂，以改善偶联/结合蛋白的性能（运动自由度）。葡聚糖可以衍生化，以用于生物传感器系统。小于60,000kDa的葡聚糖通常被认为是低分子量葡聚糖。由于粘度、聚集性和渗透性，低分子量葡聚糖通常优于高分子量葡聚糖。高分子量的水溶性葡聚糖聚合物已被用于各种生物医学应用。一种低分子量葡聚糖（15,000-30,000），可用于研究瞬时质膜透化的过程。葡聚糖（15,000-30,000）可用作蛋白质包装和折叠研究中的糖类拥挤剂。
将右旋糖酐用作长的亲水性间隔臂提高了作用于大分子的固定化蛋白质的性能。

準備報告

除了最高分子量的葡聚糖D5501（分子量范围= 500万至4,000万），其他葡聚糖都具有非常好的水溶性。 Sigma测试显示，葡聚糖在水中的溶解浓度通常超过30mg/ml。葡聚糖也易溶于DMSO、甲酰胺、乙二醇和甘油。中性-水性葡聚糖溶液可通过在110-115oC下高压灭菌30至45分钟进行灭菌。葡聚糖在高温下可以被强酸水解。葡聚糖的末端还原性端基可在碱性溶液中氧化。

其他說明

为了全面了解我们针对客户研究提供的各种葡聚糖产品，建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Thomas Rath et al.
Nephron. Clinical practice, 114(1), c81-c88 (2009-11-06)
Intravenous iron supplementation is a basic principle in the therapy of haemodialysis (HD) patients with renal anaemia. In the Iron Dextran in Renal Anaemia (IDIRA) study, we analysed the efficacy of a therapy with low-molecular-weight iron dextran (LMW-ID) in stable
Eugen Sisu et al.
Rapid communications in mass spectrometry : RCM, 20(2), 209-218 (2005-12-15)
A combined methodology for obtaining at the preparative scale and characterization by nanoelectrospray ionization (nanoESI) quadrupole time-of-flight (QTOF) mass spectrometry (MS) and tandem MS (MS/MS) of linear polysaccharides modified at the reducing end is presented. Two polydisperse maltodextrins (1000 and
R J Stenekes et al.
Biomaterials, 22(13), 1891-1898 (2001-06-09)
In this paper, a novel method is presented for the preparation of dextran hydrogels and microspheres, based on crystallization. Although dextrans are known to be well soluble in water, precipitation was observed in concentrated aqueous solutions of low molecular weight
Diego Delgado et al.
Human gene therapy, 23(4), 345-355 (2012-02-03)
The goal of the present study was to analyze the potential application of nonviral vectors based on solid lipid nanoparticles (SLN) for the treatment of ocular diseases by gene therapy, specifically X-linked juvenile retinoschisis (XLRS). Vectors were prepared with SLN
Yuichi Ozaki et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(4), 922-927 (2012-02-04)
Although an intracoronary frequency-domain optical coherence tomography (FD-OCT) system overcomes several limitations of the time-domain OCT (TD-OCT) system, the former requires injection of contrast media for image acquisition. The increased total amount of contrast media for FD-OCT image acquisition may
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Applications of Glucose Polymers in the Synthesis of Diagnostic and Drug Delivery Nanoparticles

Dmitri Simberg (University of Colorado Anschutz Medical Campus, USA) reviews the used of dextran and cyclodextrin for the synthesis of nanoparticles used in drug delivery applications.

Applications of Glucose Polymers in the Synthesis of Diagnostic and Drug Delivery Nanoparticles

Dmitri Simberg (University of Colorado Anschutz Medical Campus, USA) reviews the used of dextran and cyclodextrin for the synthesis of nanoparticles used in drug delivery applications.

实验方案

Dextran

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(1-6) linkages. The remaining a(1-3) linkages account for the branching of dextran. Conflicting data on the branch lengths implies that the average branch length is less than three glucose units. However, other methods indicate branches of greater than 50 glucose units exist.

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