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形狀
powder
起源
Sanofi Aventis
SMILES 字串
OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
InChI
1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
InChI 密鑰
KBAUFVUYFNWQFM-UHFFFAOYSA-N
基因資訊
human ... HRH1(3269)
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一般說明
多西拉敏属于乙醇胺类抗组胺药，经肝脏代谢为 N -去甲基多西拉敏和 N , N -二去甲基多西拉敏。 它通常是一种非处方药 (OTC)，用于治疗过敏和感冒症状。
應用
琥珀酸多西拉敏已被用于研究在CS培养基低视黄酸浓度的情况下，非致畸性暴露（non-teratogenic exposures ）对人胚胎干细胞聚集体（HESCA）-CSR的形态和基因表达的影响。
琥珀酸多西拉敏盐已被用作检查发育毒性的治疗药物。
生化／生理作用
H 1 组胺受体拮抗剂；催眠药。
多西拉敏抑制组胺 H1 受体。它与失眠的短期管理和普通感冒症状的暂时缓解有关。另一方面，多西拉敏中毒与横纹肌溶解和继发性急性肾功能衰竭有关。
对小鼠的研究显示，多西拉敏诱导肝微粒体细胞色素 P450 和其它与甲状腺素 (T4) 代谢有关的酶。本药与盐酸吡哆醇合用，可治疗晨吐。
多西拉敏抑制组胺 H1 受体。它与失眠的短期管理和普通感冒症状的暂时缓解有关。另一方面，多西拉敏中毒与横纹肌溶解和继发性急性肾功能衰竭有关。
对小鼠的研究显示，多西拉敏诱导肝微粒体细胞色素 P450 和其它与甲状腺素 (T4) 代谢有关的酶。本药与盐酸吡哆醇合用，可治疗晨吐。
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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