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一般說明
白喉毒素可用作细胞特异性细胞毒性免疫毒素中的毒素成分。具有天然内体逃逸机制的细菌毒素易位结构域已被用于开发有效的非病毒载体用于基因治疗。
應用
白喉棒状杆菌的白喉毒素已用于：
- 小胶质细胞耗竭，研究小鼠创伤后应激障碍
- 腹腔注射转基因小鼠，以在消融过程中融合移植的造血干细胞和祖细胞（HSPCs）后选择杂交种
- 研究其对嗜酸性粒细胞缺陷小鼠株（iPHIL）中嗜酸性粒细胞系祖细胞的影响
生化／生理作用
白喉毒素是一种由白喉棒状杆菌产生的细菌毒素。它包含三个具有细胞内作用的结构域。这些结构域参与细胞中毒、细胞表面结合和内化为内体、穿过内体膜转运到胞质溶胶并抑制细胞蛋白质合成。白喉毒素可用于构建生物技术工具和治疗方法。它通过催化真核生物中靶蛋白的二磷酸腺苷（ADP）核糖基化来抑制蛋白质合成。
外觀
含Tris和EDTA的冻干粉。
重構
当用无菌蒸馏水将每管重悬至0.5 mL时，0.01 M Tris和0.001 M Na2EDTA，pH 7.5中含有~1 mg的白喉毒素。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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