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一般說明
Diphtheria toxin may be used as a toxin element in the construction of immunotoxin for cell-specific cytotoxicity. The translocation domain of bacterial toxins with a natural endosome escape mechanism has been used in the development of efficient nonviral vectors for applications in gene therapy.
應用
白喉棒状杆菌的白喉毒素已用于：
- 小胶质细胞耗竭，研究小鼠创伤后应激障碍
- 在转基因小鼠中腹膜内注射，以在消融过程中融合移植的造血干细胞和祖细胞（HSPCs）后选择杂交种
- 研究其对嗜酸性粒细胞缺陷小鼠株（iPHIL）中嗜酸性粒细胞谱系转化祖细胞的影响
生化／生理作用
白喉毒素是一种由白喉棒状杆菌产生的细菌毒素。它包含三个具有细胞内作用的结构域。这些结构域参与细胞中毒、细胞表面结合和内化为内体、穿过内体膜转运到胞质溶胶并抑制细胞蛋白质合成。白喉毒素可用于构建生物技术工具和治疗方法。它通过催化真核生物中靶蛋白的二磷酸腺苷（ADP）核糖基化来抑制蛋白质合成。
外觀
含Tris和EDTA的冻干粉。
重構
当用无菌蒸馏水将每管重悬至0.5 mL时，0.01 M Tris和0.001 M Na2EDTA，pH 7.5中含有~1 mg的白喉毒素。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
儲存類別代碼
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
S M Yellon et al.
Biology of reproduction, 100(5), 1386-1394 (2019-01-11)
To test the hypothesis that macrophages are essential for remodeling the cervix in preparation for birth, pregnant homozygous CD11b-dtr mice were injected with diphtheria toxin (DT) on days 14 and 16 postbreeding. On day 15 postbreeding, macrophages (F4/80+) were depleted
Biology and molecular epidemiology of diphtheria toxin and the tox gene
The Journal of Infectious Diseases, 181 (2000)
Mary F Fontana et al.
PLoS pathogens, 12(12), e1006046-e1006046 (2016-12-07)
Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. Here we show that myeloid expansion
Benjamin J Vakoc et al.
Nature medicine, 15(10), 1219-1223 (2009-09-15)
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous contrast agents that enable multiphoton microscopy, however, limit the ability
Vicky A Tobin et al.
Nature, 464(7287), 413-417 (2010-02-26)
Many peptides, when released as chemical messengers within the brain, have powerful influences on complex behaviours. Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now known to be released
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