所有图片(1)
About This Item
经验公式（希尔记法）:
C30H28N6O6S4
CAS号:
分子量:
696.84
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥95% (HPLC)
形狀
powder
儲存溫度
2-8°C
SMILES 字串
CN1C(=O)C23CC4(C(Nc5ccccc45)N2C(=O)C1(CO)SS3)C67CC89SSC(CO)(N(C)C8=O)C(=O)N9C6Nc%10ccccc7%10
InChI
1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3
InChI 密鑰
PZPPOCZWRGNKIR-UHFFFAOYSA-N
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一般說明
毛壳素是一种具有抗菌和细胞抑制活性的真菌代谢物。它属于3,6-附睾硫代二酮哌嗪类，与胶质瘤毒素、孢子虫素、蜘蛛素、米扎氯、黄萎病素A和榅桲杀菌素属同一类。毛壳素是由两个五元环顺式融合而成的分子二聚体。
應用
来自毛壳菌属的毛壳素已用于测定对各种细胞的敏化作用。它还用于策动OS诱导异染色质形成的生物学功能。
生化／生理作用
毛壳素是S-腺苷甲硫氨酸的竞争性抑制剂。毛壳素对SU(VAR)3-9的特异性使该化合物成为研究异染色质介导基因抑制的极好工具。
毛壳素是一种抗菌霉菌毒素。作为赖氨酸特异性组蛋白甲基转移酶的特异性抑制剂，该化合物适合用于研究异染色质介导基因抑制。毛壳素是硫氧还蛋白还原酶-1 (TrxR1)的选择性竞争抑制剂，是其抗癌活性的公认机制。
甲基转移酶，帮助化合物用于异染色质介导的基因抑制研究。
準備報告
溶于DMSO。 在1mg / ml时，溶液在2-8℃下稳定1周。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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商品
Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.
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