生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~24 kDa (and ~28 kDa)
物種活性
human, rat, mouse
技術
western blot: 1:250-1:500 using whole extracts of mouse and rat liver and HEK-293T cells expressing human COMT
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... COMT(1312)
mouse ... Comt1(12846)
rat ... Comt(24267)
一般說明
The gene Catechol-O-methyltransferase (COMT) is mapped to human chromosome 22q11.2. COMT is also referred to as HEL-S-98n. It is widely expressed in various tissues, including brain, liver, kidney, endometrium and breast.
特異性
The antibody recognizes MB-COMT and S-COMT.
應用
Anti-COMT (N-terminal) antibody produced in rabbit has been used in immunoblotting.
生化／生理作用
Catechol-O-methyltransferase (COMT) is a Mg2+-dependent enzyme. COMT catalyzes transfer of methyl groups from S-adenosyl methionine to catecholamines. It is responsible for degradation of catecholamines and thereby results in psychiatric disorders and symptoms. Met/Met genotype individuals can acquire skill in executive function tasks (as multi-unmanned vehicles supervisory control, to a higher level and/or faster than other genotype groups). On the other hand, COMT polymorphism is linked to major depressive disorder and bipolar disorder. The genetic variants of COMT alter neurobehavioral functions that are affected by mercury in adults and might modify the adverse neurobehavioral effects of mercury exposure in children. COMT polymorphism is associated with high risk of premature ovarian insufficiency. COMT single nucleotide polymorphism preoperative humans psychological status and postoperative opioid analgesia efficacy. COMT acts as a tumor supressor gene for colorectal cancer cell lines. Overexpression of COMT supresses pancreatic cancer.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Emerson Barchi Cordts et al.
Journal of ovarian research, 7, 47-47 (2014-05-09)
Estrogens are important factors in the female reproductive functions and are processed by a number of enzymes along their metabolic pathway. The COMT gene constitutes a crucial element in estrogen metabolism and is assumed to be involved in the development
Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models
Maasz G, et al.
Disease models & mechanisms, 10(2), 127-139 (2017)
A L Potapov et al.
Anesteziologiia i reanimatologiia, 60(3), 48-51 (2015-09-30)
To evaluate the influence of µl-opioid receptor (OPRM1) 118A>G and catechol-O-methyltransferase (COMT) 1947G>A gene single nucleotide polymorphisms (SNP) combinations on postoperative opioid analgesia (POA) efficacy. In 100 consecutive patients scheduled for major urologic surgeries the SNPs of OPRM1 118A>G and
G Pandolfo et al.
Journal of affective disorders, 177, 108-113 (2015-03-15)
Major depressive disorder (MDD) and bipolar disorder (BD) are the two most common mood disorders. Given the recognized involvement of catecholamines in depression, genetic research focused on the evaluation of polymorphisms in genes coding for proteins that regulate neurotransmitter release
Wenming Wu et al.
Archives of medical research, 46(1), 17-23 (2014-12-24)
Catechol-O-methyltransferase (COMT) has been reported as an important molecule in various types of cancers. The biological function of COMT in colorectal cancer (CRC) has not yet been fully investigated. We constructed a transient transfection of a CRC cell lines to
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