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C5865

Sigma-Aldrich

CD437

≥98% (HPLC), solid

别名:

6- [3-（1-金刚烷基）-4-羟苯基] -2-萘甲酸, AHPN

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About This Item

经验公式（希尔记法）:
C27H26O3
CAS号:
125316-60-1
分子量:
398.49
MDL號碼:
MFCD03106506
分類程式碼代碼:
12352200
PubChem物質ID:
24724445
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

雜質

~0.5 mol/mol water

顏色

yellow

mp

271.6-276 °C

溶解度

DMSO: >10 mg/mL
H2O: insoluble

儲存溫度

−20°C

SMILES 字串

OC(=O)c1ccc2cc(ccc2c1)-c3ccc(O)c(c3)C45CC6CC(CC(C6)C4)C5

InChI

1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)

InChI 密鑰

LDGIHZJOIQSHPB-UHFFFAOYSA-N

基因資訊

human ... RARA(5914) , RARB(5915) , RARG(5916)

生化／生理作用

CD437 是视黄酸受体（RAR）γ-选择性激动剂，γ-选择性视黄酸；凋亡的有效诱导剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
022M4623V
068K46292
068K46291
068K4629
057K4610

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Retinoic acid signaling plays key roles in embryonic development and in maintaining the differentiated status of adult tissues. Recently, the nuclear retinoic acid receptor (RAR) isotypes α, β and γ were found to play specific functions in the expansion and
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Acute myeloid leukemia (AML) is one of the most frequent types of blood malignancies. It is a complex disorder of undifferentiated hematopoietic progenitor cells. The majority of patients generally respond to intensive therapy. Nevertheless, relapse is the major cause of
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Journal of molecular signaling, 5, 12-12 (2010-08-14)
A variety of pathways target CDKI p21WAF1/CIP1 expression at transcriptional, post-transcriptional as well as translational levels. We previously found that cell growth suppressing retinoid CD437 enhanced expression of p21WAF1/CIP1 and DNA damage inducible GADD45 proteins in part by elevating their
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All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apoptosis, and embryonic development.

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