生物源
mouse
品質等級
重組細胞
expressed in NS.1 cells
化驗
≥99% (SDS-PAGE)
形狀
buffered aqueous solution
分子量
97 kDa
包裝
pkg of 1 mg
儲存條件
avoid repeated freeze/thaw cycles
雜質
≤1 EU/mg protein Endotoxin level (LAL test)
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... Cd152(12477) , Ctla4(12477)
一般說明
The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
生化／生理作用
CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
其他說明
The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.
外觀
Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
準備報告
Purified from serum-free tissue culture supernatant
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Amod A Sarnaik et al.
Cancer journal (Sudbury, Mass.), 15(3), 169-173 (2009-06-27)
Metastatic melanoma is a disease associated with poor prognosis, with a median survival reported to range from 6 to 9 months. Patients who are not candidates for surgical resection have an even worse expected survival. This is largely due to
W Steurer et al.
Journal of immunology (Baltimore, Md. : 1950), 155(3), 1165-1174 (1995-08-01)
To test the hypothesis that blockade of B7-triggered costimulation by donor cells could preclude allograft rejection, we coated crude islet allograft preparations in vitro for 1 h with a murine CTLA4/Fc fusion protein. Murine CTLA4/Fc blocks the proliferative response in
Andrew L Mellor et al.
International immunology, 16(10), 1391-1401 (2004-09-08)
Murine dendritic cells (DCs) expressing indoleamine 2,3 dioxygenase (IDO) catabolize tryptophan and can suppress T cell responses elicited in vivo. Here, we identify specific subsets of splenic (CD11c+) dendritic cells competent to mediate IDO-dependent T cell suppression following CTLA4-mediated ligation
Andrew L Mellor et al.
Journal of immunology (Baltimore, Md. : 1950), 171(4), 1652-1655 (2003-08-07)
In mice, immunoregulatory APCs express the dendritic cell (DC) marker CD11c, and one or more distinctive markers (CD8alpha, B220, DX5). In this study, we show that expression of the tryptophan-degrading enzyme indoleamine 2,3 dioxygenase (IDO) is selectively induced in specific
P S Linsley et al.
The Journal of experimental medicine, 174(3), 561-569 (1991-09-01)
Functional interactions between T and B lymphocytes are necessary for optimal activation of an immune response. Recently, the T lymphocyte receptor CD28 was shown to bind the B7 counter-receptor on activated B lymphocytes, and subsequently to costimulate interleukin 2 production
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