C213040

DMT-2′O-TBDMS-rC(ac)亚磷酰胺

configured for MerMade

• 别名: N-乙酰基5＆＃8242; -O- [双（4-甲氧基苯基）苯基甲基] -2＆＃8242; -O-[（1,1-二甲基乙基）二甲基甲硅烷基]-胞苷，3＆＃8242;-[2-氰基乙基N，N-双（1-甲基乙基）亚磷酰胺]
• 经验公式（希尔记法）: C₄₇H₆₄N₅O₉PSi
• CAS号: 121058-88-6
• 分子量: 902.10
• MDL號碼: MFCD09842111
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329774950
• NACRES: NA.51

属性

• 生物源: non-animal source (no BSE/TSE risk)
• 品質等級: 300
• 產品線: Proligo Reagents
• 化驗: ≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• 形狀: powder
• 技術: oligo synthesis: suitable
• 雜質: ≤0.3% water content (Karl Fischer); ≤0.5% P(III) Impurities 100-169ppm (³¹P-NMR); ≤0.5% single Impurity (reversed phase HPLC); ≤3% residual Solvent content
• 顏色: white to off-white
• &lambda ；: conforms (UV/VIS Identity)
• 適合性: conforms to structure for H-NMR; conforms to structure for LC-MS
• 相容性: configured for MerMade
• 核苷譜: base: cytidine; base protecting group: acetyl; 2' protecting group: TBDMS; 5' protecting group: DMT; deprotection: fast/standard
• 儲存溫度: −20°C
• SMILES 字串: COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(C)=O)=NC3=O)(c4ccccc4)c5ccc(OC)cc5
• InChI: 1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1
• InChI 密鑰: QKWKXYVKGFKODW-YOEDQOPESA-N

说明

一般說明

RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness.Key Features:

• Industry-standard 2′O-TBDMS protective group
• Consistent lot-to-lot purity and performance
• Compatible with deprotection methods based on methylamine or AMA
• Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are btained with activator 42
• Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A
• Manufactured under a certified ISO 9001 quality system

DMT-2′O-TBDMS-rC(ac) Phosphoramidite is configured for MerMade Synthesizers.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable