推荐产品
形狀
powder
品質等級
儲存溫度
2-8°C
SMILES 字串
Cl.CN(C)CC\C=C1\c2ccccc2Sc3ccc(Cl)cc13
InChI
1S/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H/b14-7-;
InChI 密鑰
YWKRLOSRDGPEJR-KIUKIJHYSA-N
基因資訊
human ... DRD2(1813) , DRD3(1814) , HTR2A(3356) , HTR2C(3358)
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一般說明
氯普噻吨为精神安定药,属噻吨类。它具有抗胆碱药作用。氯普噻吨可能与梗阻性黄疸和帕金森综合征有关。用于治疗精神病。
應用
用盐酸氯普噻吨研究了其暴露对大鼠学习和记忆的影响。
生化/生理作用
D2多巴胺受体拮抗剂;阻断大鼠皮层中GABAA受体的一个子集,该子集也被氯氮平阻断;硫黄嘌呤类抗精神病药。
訊號詞
Danger
危險聲明
防範說明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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Conformational analyses have been performed on several phenothiazine and thioxanthene dopamine antagonists using the MM2-87 program and parameter set. The compounds that were examined are thioridazine (2), methotrimeprazine (3), cis- and trans-chlorprothixene, and a piperidylidene derivative of chlorprothixene. In addition
Cell reports, 37(6), 109972-109972 (2021-11-11)
Cortical function relies on the balanced activation of excitatory and inhibitory neurons. However, little is known about the organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons. Here, we use the excitatory postsynaptic marker PSD-95, fluorescently labeled at
Desk Reference of Clinical Pharmacology, Second Edition (1997)
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