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品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: >10 mg/mL
SMILES 字串
Cl.CC(C)(C)NCC(O)COc1cccc2NC(=O)Nc12
InChI
1S/C14H21N3O3.ClH/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10;/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19);1H
InChI 密鑰
YQVFCYCTITZLSX-UHFFFAOYSA-N
基因資訊
human ... ADRB1(153) , ADRB2(154) , ADRB3(155)
應用
(±)-CGP-12177A has been used as a β-Adrenergic receptor agonist:
- to evaluate the dissociation constant (Kd) by frontal affinity chromatography
- to study its cardiostimulant effects on rat ventricular cardiomyocytes
- to study its binding affinity in α1D-adrenoceptors expressed in rat BHK-21 cells
生化／生理作用
β-adrenoceptor nonconventional partial agonist.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
J Oostendorp et al.
British journal of pharmacology, 130(4), 747-758 (2000-06-24)
The smooth muscle relaxant responses to the mixed beta(3)-, putative beta(4)-adrenoceptor agonist, (-)-CGP 12177 in rat colon are partially resistant to blockade by the beta(3)-adrenoceptor antagonist SR59230A suggesting involvement of beta(3)- and putative beta(4)-adrenoceptors. We now investigated the function of
P Oliver et al.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 24(4), 423-428 (2000-05-11)
To assess the effect of chronic treatment with CGP-12177 a beta3-adrenergic receptor (AR) agonist with beta2/beta1-AR antagonist action, on the expression of the leptin gene and of genes coding for uncoupling proteins (ucp1, ucp2 and ucp3) in brown and white
Maura Floreani et al.
European journal of pharmacology, 590(1-3), 303-309 (2008-07-01)
Recent in vitro studies, performed in rat aorta, mesenteric and intrapulmonary arteries, and human pulmonary artery, demonstrated that the beta-adrenoceptor ligand CGP-12177A (4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one) is also provided with antagonist or partial agonist properties at alpha(1)-adrenoceptors. These observations were supported by estimates
Clive J Lewis et al.
British journal of pharmacology, 141(5), 813-824 (2004-02-06)
1. CGP 12177A mediates cardiostimulation by activation of the 'putative' beta(4)-adrenoceptor; however, it has recently been reported that disruption of the beta(1)-adrenoceptor gene abolishes this effect. We have adenovirally overexpressed beta(1)-adrenoceptors in isolated, cultured adult rat ventricular cardiomyocytes and observed
Y Yamamoto et al.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 36(1), 13-19 (2000-06-01)
In the present study, we tried to determine what effects were induced by beta-adrenoceptor agonists on 40 mM KCl-induced rhythmic contraction and to clarify which beta-adrenoceptor subtypes are involved in the regulation of ureter motility in the guinea pig by
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