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生物源
rat
品質等級
化驗
≥95% (HPLC)
形狀
powder
分子量
3803.25-3809.25 Da
技術
cell based assay: suitable
序列說明
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
儲存溫度
−20°C
基因資訊
rat ... Calca(24241)
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Amino Acid Sequence
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
一般說明
Research area: Neuroscience
Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system.
Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system.
應用
Calcitonin Gene Related Peptide rat has been used:
- To study its protective role in lipopolysaccharide (LPS)-induced acute lung injury (ALI).
- To examine the effects of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric lesions and mucosal barrier in stress induced rats.
- To mediate the complement component 5a (C5a) induced mechanical hypersensitivity by activating nerve fibers and influencing non-neuronal cell movement through its receptor.
生化／生理作用
Calcitonin gene related peptide (CGRP) is a potent vasodilator produced from sensory fibers, acting as transmitters in the peripheral and central nervous system, thereby exerting its role in regulating pain and cardiovascular activity. CGRPs play an important role in regulating systemic blood pressure, and microvascular dilatation and are associated with hyperemia. It stimulates edema in orofacial tissue and its activation in pancreatic β-cells increases plasma levels of pancreatic enzymes. In addition, CGRP also induces DNA synthesis and cell proliferation in endothelial cells.
Potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
其他說明
Lyophilized from 0.1% TFA in H2O
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Exogenous alpha-calcitonin gene-related peptide attenuates lipopolysaccharide-induced acute lung injury in rats
Yang W, et al.
Molecular Medicine Reports, 12(2), 2181-2188 (2015)
Calcitonin gene-related peptide is a potent vasodilator
Brain SD, et al.
Nature, 313(5997), 54-54 (1985)
Effects of salmon calcitonin and calcitonin gene related peptide (CGRP) on gastric mucosal barrier in stress induced rats
Kanay Z, et al.
African Journal of Biotechnology, 8(8) (2009)
Effect of calcitonin gene-related peptide on anastomotic healing in the presence of endotoxin
Dogmucs M, et al.
ANZ Journal of Surgery, 75(12), 1106-1110 (2005)
Charles A Warwick et al.
Pain, 160(3), 702-711 (2018-12-07)
The complement system significantly contributes to the development of inflammatory and neuropathic pain, but the underlying mechanisms are poorly understood. Recently, we identified the signaling pathway responsible for thermal hypersensitivity induced by the complement system component C5a. Here, we examine
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