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C0289

Sigma-Aldrich

胆固醇亚油酸酯

≥98% (HPLC; detection at 205 nm)

别名:

5-胆甾烯-3β-醇 3-亚油酸酯, 胆固醇十八碳二烯酸酯, 胆甾烯基亚油酸酯, 胆甾醇亚油酸酯

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About This Item

经验公式（希尔记法）:
C45H76O2
CAS号:
604-33-1
分子量:
649.08
EC號碼:
210-065-9
MDL號碼:
MFCD00003644
分類程式碼代碼:
12352211
PubChem物質ID:
24892247
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

200

化驗

≥98% (HPLC; detection at 205 nm)

形狀

powder

官能基

ester

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

CCCCC\C=C/C\C=C/CCCCCCCC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC=C2C1)[C@H](C)CCCC(C)C

InChI

1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1

InChI 密鑰

NAACPBBQTFFYQB-LJAITQKLSA-N

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相关类别

應用

将胆固醇亚油酸酯与胆固醇共超声制备分散液，研究其对红细胞膜胆固醇磷脂比的影响。作为 HPLC 标准品用于分析大鼠肝脏脂蛋白。

生化／生理作用

低密度脂蛋白 (LDL) 中含量最丰富的胆固醇酯。
胆固醇亚油酸是一种主要的胆固醇酯，与低密度脂蛋白的中性核心有关。受体-LDL 复合物被溶酶体摄取并水解以从酯中释放胆固醇。酸性胆固醇酯水解酶负责胆固醇酯的水解；有缺陷的酶可导致人体动脉粥样硬化病变的形成。

包裝

密封安瓿瓶

準備報告

胆固醇亚油酸在氯仿中生成澄清无色溶液，浓度为 100 mg/mL。

相關產品

产品编号
说明
价格

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCL6238
SLCB7744
SLBX5428
SLBT3878
SLBS9356

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J Christison et al.
The Biochemical journal, 314 ( Pt 3), 739-742 (1996-03-15)
To test whether high-density lipoproteins (HDL) could aid in the removal in vivo of potentially atherogenic oxidized lipids, we perfused rat liver in situ with buffer supplemented with isolated human HDL containing small amounts of cholesteryl linoleate hydro(pero)xides [CH18:2-O(O)H]. Perfusion
Y Yamamoto
Free radical research, 33(6), 795-800 (2001-03-10)
Cholesteryl ester hydroperoxide (CE-OOH) and phosphatidylcholine hydroperoxide (PC-OOH) are the major primary oxidation products of lipoproteins. CE-OOH is present in human and rat plasmas while PC-OOH is undetectable. This is likely due to the enzymatic (plasma glutathione peroxidase) and the
J K Christison et al.
Journal of lipid research, 36(9), 2017-2026 (1995-09-01)
This study examines the cholesteryl ester transfer protein (CETP)-mediated exchange of cholesteryl linoleate hydroperoxide (Ch18:2-OOH) and cholesteryl linoleate hydroxide (Ch18:2-OH) between low density lipoprotein (LDL) and high density lipoprotein (HDL). When [3H]Ch18:2-OOH- and [3H]18:2-OH-labeled LDL were incubated at 37 degrees
Ota Samek et al.
Sensors (Basel, Switzerland), 10(9), 8635-8651 (2010-01-01)
Algae are becoming a strategic source of fuels, food, feedstocks, and biologically active compounds. This potential has stimulated the development of innovative analytical methods focused on these microorganisms. Algal lipids are among the most promising potential products for fuels as
R Mashima et al.
Journal of lipid research, 41(1), 109-115 (2000-01-11)
We have previously reported the detection of cholesteryl ester hydroperoxides, consisting mainly of cholesteryl linoleate hydroperoxides (Ch18:2-OOH), at nm levels in plasma from healthy humans (Y. Yamamoto and E. Niki, 1989. Biochem. Biophys. Res. Commun. 165: 988-993). To elucidate their
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Cholesterol Esterification

Cholesterol undergoes esterification to improve transport. Cholesterol esters are more easily packaged into the interior of lipoproteins - increasing the quantity that can be readily transported in the blood stream.

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