跳转至内容
Merck

B6542

Sigma-Aldrich

布雷菲德菌素 A

≥99% (HPLC and TLC), BioXtra, for molecular biology

别名:

γ,4-二羟基-2-(6-羟基-1-庚烯基)-4-环戊烯丁烯酸λ-内酯, Ascotoxin, BFA, 布雷菲德菌素 A, 烟碱

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C16H24O4
CAS号:
分子量:
280.36
Beilstein:
25191
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.52

生物源

Penicillium brefeldianum

品質等級

等級

for molecular biology

產品線

BioXtra

化驗

≥99% (HPLC and TLC)

形狀

powder

分子量

280.36

溶解度

DMSO: 10 mg/mL (Store stock solutions at -20 °C)

抗生素活性譜

neoplastics

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1

InChI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

InChI 密鑰

KQNZDYYTLMIZCT-KQPMLPITSA-N

正在寻找类似产品? 访问 产品对比指南

一般說明

化学结构:大环内酯
布雷菲德菌素可诱导CtBP1/BARS蛋白的ADP核糖基化,从而调节胞内运输和分泌蛋白从内质网到高尔基体的运动。

應用

适用于分泌蛋白和细胞内转运机制的分子生物学研究

生化/生理作用

布雷菲德菌素A(BFA)是一种会破坏高尔基体的结构和功能的真菌代谢产物。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。

原則

布雷菲德菌素是一种真菌代谢产物,可通过破坏高尔基体来破坏真核细胞中的蛋白质分泌。它不会影响蛋白质合成过程。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

防範說明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Y Misumi et al.
The Journal of biological chemistry, 261(24), 11398-11403 (1986-08-25)
We examined the effect of brefeldin A, an antiviral antibiotic, on protein synthesis, intracellular processing, and secretion in primary culture of rat hepatocytes. The secretion was strongly blocked by the drug at 1 microgram/ml and higher concentrations, while the protein
Marco Lepore et al.
Nature communications, 5, 3866-3866 (2014-05-17)
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic MHC class I-like molecule MR1. Here we show that human MAIT cells are remarkably oligoclonal in both the
Laura Jeanbart et al.
Cancer immunology research, 2(5), 436-447 (2014-05-06)
The sentinel or tumor-draining lymph node (tdLN) serves as a metastatic niche for many solid tumors and is altered via tumor-derived factors that support tumor progression and metastasis. tdLNs are often removed surgically, and therapeutic vaccines against tumor antigens are
Anniek B van der Waart et al.
Blood, 124(23), 3490-3500 (2014-10-23)
Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell-like T cells with the ability to self-renew and differentiate into potent effector cells. Here, we investigated the in vivo existence of stem cell-like antigen-specific T cells
Emma M Haapaniemi et al.
Blood, 125(4), 639-648 (2014-10-29)
The signal transducer and activator of transcription (STAT) family of transcription factors orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development of immunodysregulation polyendocrinopathy enteropathy X-linked-like syndrome. Here, we immunologically characterized 3 patients

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门