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化驗
≥98% (HPLC)
形狀
oil
顏色
light yellow
溶解度
DMSO: freely soluble
ethanol: freely soluble
起源
Bayer
儲存溫度
−20°C
SMILES 字串
CCCC1(CCC1)[C@H](O)C\C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC
InChI
1S/C24H40O5/c1-3-14-24(15-9-16-24)22(27)12-8-11-19-18(20(25)17-21(19)26)10-6-4-5-7-13-23(28)29-2/h8,11,18-19,21-22,26-27H,3-7,9-10,12-17H2,1-2H3/b11-8+/t18-,19-,21-,22-/m1/s1
InChI 密鑰
XRISENIKJUKIHD-LHQZMKCDSA-N
應用
（R）-布他前列素已被用作前列腺素受体（EP）特异性激动剂，用于研究其对MCF7细胞中蛋白激酶A（PKA）调节亚基的作用。它可用作在马丁达比（Madin-Darby）狗肾和小鼠皮质集合管（mpkCCD14）细胞的EP2激动剂。它也可用作人胚肺成纤维细胞（HFL-1）的EP2激动剂，用于测试其对血管内皮生长因子（VEGF）生成的影响。
生化／生理作用
布他前列素包含羟基-环戊酮环和ω-链。它在谷氨酸盐N-甲基-D-天冬氨酸受体毒性中提供保护作用。在青光眼滤过手术后，布他前列素可抑制结膜纤维化并降低眼内压。它还通过减少结膜下瘢痕Tenons′成纤维细胞而促进伤口愈合。布他前列素在肺纤维化中起保护作用，并有助于防止阿尔茨海默氏′病中淀粉样蛋白β（Aβ）肽的聚集。
(R)-布他前列素是一种选择性 EP 2 前列腺素受体激动剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Terence Peters et al.
The Journal of pharmacology and experimental therapeutics, 335(2), 424-433 (2010-08-07)
Protease-activated receptors (PARs) are widely expressed throughout the respiratory tract, and PAR(2) has been investigated as a potential drug target for inflammatory airway diseases. The primary focus of this study was to determine the extent to which PAR(2)-activating peptides modulate
Boris P L Lee et al.
International immunopharmacology, 9(5), 534-539 (2009-06-23)
Limited data are available on the mechanisms that constrain the function of regulatory populations of T cells. Prostaglandin E2 (PGE2) is an endogenous membrane phospholipid metabolite that has important immunomodulatory effects on T cell function. Our previous microarray data indicated
K J af Forselles et al.
British journal of pharmacology, 164(7), 1847-1856 (2011-05-21)
Studies of the role of the prostaglandin EP(2) receptor) have been limited by the availability of potent and selective antagonist tools. Here we describe the in vitro/in vivo pharmacological characterization of a novel EP(2) receptor antagonist, PF-04418948 (1-(4-fluorobenzoyl)-3-{[(6-methoxy-2-naphthyl)oxy]methyl} azetidine-3-carboxylic acid).
Structural features of subtype-selective EP receptor modulators
Markovivc T, et al.
Drug Discovery Today, 22(1), 57-71 (2017)
The vasopressin type 2 receptor and prostaglandin receptors EP2 and EP4 can increase aquaporin-2 plasma membrane targeting through a cAMP-independent pathway
Olesen ETB, et al.
American Journal of Physiology: Renal Physiology, 311(5), F935-F944 (2016)
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