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應用
ADP-核糖基环化酶是Ca2+信号传递的一种第二信使。 它可用于研究钙信号转导并已被用于研究吗啡的抗伤害作用和耐受性。
生化／生理作用
ADP-核糖基环化酶是一种可将NAD环化为cADPR的细胞内钙调节剂。大脑中绝大多数的ADP-核糖基环化酶活性都被认为与CD38相关。 烟酰胺是一种已知的CD38 ADP-核糖基环化酶活性抑制剂。
單位定義
在 pH 7.0、25°C 下，一单位可在5分钟内从β-NAD+产生1 μmole的环状ADP核糖。
外觀
冻干粉，含海藻糖、磷酸钾以及二硫苏糖醇
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Heather S Loring et al.
Biochemistry, 59(8), 933-942 (2020-02-13)
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly, SARM1 knockdown or knockout prevents degeneration, thereby demonstrating that SARM1
Lynn C Hull et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 1042-1050 (2010-06-17)
Our previous studies have demonstrated that an increase in intracellular levels of Ca(2+) in neurons is an important component of both the antinociception produced by morphine and morphine's tolerance. The present study tested the hypothesis that the Ca(2+) signaling second
H C Lee et al.
Cell regulation, 2(3), 203-209 (1991-03-01)
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin
Heather S Loring et al.
Bioorganic & medicinal chemistry, 28(18), 115644-115644 (2020-08-24)
Sterile Alpha and Toll Interleukin Receptor Motif-containing protein 1 (SARM1) is a key therapeutic target for diseases that exhibit Wallerian-like degeneration; Wallerian degeneration is characterized by degeneration of the axon distal to the site of injury. These diseases include traumatic
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