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種類
Grade II
形狀
salt-free, lyophilized powder
比活性
300-1,500 units/mg protein
UniProt登錄號
儲存溫度
−20°C
基因資訊
pig ... ACY1(396930)
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應用
猪肾中的酰化酶I已被用于研究各种S-烷基-N-乙酰基-L-半胱氨酸及其碳、氧类似物的酰化酶I催化的脱乙酰作用。 酰化酶I可能有助于催化N-乙酰氨基酸生成对映体纯的 L-氨基酸。
生化／生理作用
酰化酶I是一种锌金属蛋白，可催化非天然和很少发生的α氨基酸的动力学分解。它对N-酰基L-α-氨基酸水解的对映选择性几乎是绝对的，但它接受具有广泛结构和功能性的底物。酰化酶I催化N-乙酰基-L-半胱氨酸和S-烷基-N-乙酰基-L-半胱氨酸的脱乙酰化。正丁基丙二酸是酰化酶I的抑制剂。S-烷基-N-乙酰基-L-半胱氨酸与短(C0-C3)和不分枝S-烷基取代已被发现是良好的酰化酶I底物。
單位定義
一个单元将在pH 7.0和25℃条件下每小时水解1.0 μmole N-乙酰-L-蛋氨酸。
分析報告
通过缩二脲法测定的蛋白质。
訊號詞
Danger
危險分類
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Kinetic resolution of unnatural and rarely occurring amino acids: enantioselective hydrolysis of N-acyl amino acids catalyzed by acylase I
Chenault HK, et al.
Journal of the American Chemical Society, 111(16), 6354-6364 (1989)
A S Bommarius et al.
Annals of the New York Academy of Sciences, 672, 126-136 (1992-11-30)
The method of measuring enzyme deactivation by monitoring necessary addition of fresh enzyme to keep a constant degree of conversion in a CSTR at constant [E] x tau, the product of concentration of active enzyme [E] and residence time tau
V Uttamsingh et al.
Chemical research in toxicology, 11(7), 800-809 (1998-07-22)
The aminoacylase that catalyzes the hydrolysis of N-acetyl-L-cysteine (NAC) was identified as acylase I after purification by column chromatography and electrophoretic analysis. Rat kidney cytosol was fractionated by ammonium sulfate precipitation, and the proteins were separated by ion-exchange column chromatography
Keya Cai et al.
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 24(2), 285-290 (2008-05-10)
Three model silkworms, highly resistant strain, highly susceptible strain and their near isogenic line were established by hybridization and backcross. The resistance of silkworm (Bombyx mori L.) to BmNPV was studied at proteomic level using two-dimensional gel electrophoresis and MALDI
Xiaoyong Liu et al.
Journal of invertebrate pathology, 105(1), 84-90 (2010-05-18)
Silkworm hemolymph is an important defense tissue to resist bacteria and virus infections. To study the response of silkworm hemolymph in the resistance of Bombyx mori L. nucleopolyhedrovirus (BmNPV), we constructed a near-isogenic silkworm line with BmNPV resistance using highly
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