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生物源
mouse
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
hABH2-7, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~30 kDa
物種活性
human
技術
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract of 293T cells
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ALKBH2(121642)
一般說明
Anti-hABH2 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hABH2-7 hybridoma produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a synthetic peptide of human hABH2, conjugated to KLH. Human alkB homolog 1, histone H2A dioxygenase (hABH2) shares homology with the AlkB protein in bacteria. hABH2 localizes to the nucleoplasm and occasionally to the nucleoli.
應用
Mouse Monoclonal Anti-hABH2 antibody has been used for western blot assays. The antibody can also be used for IHC, ELISA, microarray, and immunoprecipitation studies.
生化／生理作用
Removal of the methyl groups of 1-methyladenine (1-meA) and 3-methylcystosine (3-meC) to their unmodified forms is done by human alkB homolog 1, histone H2A dioxygenase (hABH2) and hABH3. hABH2 acts on double stranded DNA.
hABH2 is a Fe (II) dependent dioxygenase involved in the repair of alkylation-induced damage in double stranded DNA. Alterations in hABH2 have been linked to pediatric brain tumor and gastric cancer.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase
Koivisto P, et al.
The Journal of Biological Chemistry, 278(45), 44348-44354 (2003)
Reversal of DNA alkylation damage by two human dioxygenases
Duncan T, et al.
Proceedings of the National Academy of Sciences of the USA, 99(26), 16660-16665 (2002)
Wei Gao et al.
Journal of gastroenterology and hepatology, 26(3), 577-584 (2010-12-16)
Methyl or 1, N(6) -ethenoadenine base lesions are frequent and highly-mutagenic or -carcinogenic events in mammalian DNA. Human AlkB homologue-2 (hABH2), a homologue of the Escherichia coli AlkB protein, has been found to be the principal dioxygenase for the repair
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
Aas PA, et al.
Nature, 421(6925), 859-859 (2003)
Tor-Christian Aase Johannessen et al.
Neuro-oncology, 15(3), 269-278 (2012-12-22)
Glioblastoma multiforme (GBM; World Health Organization astrocytoma grade IV) is the most frequent and most malignant primary brain tumor in adults. Despite multimodal therapy, all such tumors practically recur during the course of therapy, causing a median survival of only
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