跳转至内容
Merck

A8054

Sigma-Aldrich

D(-)-2-氨基-5-膦戊酸

NMDA receptor antagonist

别名:

D -2-氨基-5-膦酰戊酸, D(-)-AP-5, D(-)-APV

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C5H12NO5P
CAS号:
分子量:
197.13
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.26

品質等級

化驗

≥98% (TLC)

形狀

powder

光學純度

optical purity: ≥90% (HPLC, Marfey′s reagent)

技術

ligand binding assay: suitable

顏色

white

mp

245-246 °C

SMILES 字串

N[C@H](CCCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1

InChI 密鑰

VOROEQBFPPIACJ-SCSAIBSYSA-N

正在寻找类似产品? 访问 产品对比指南

應用

D (-)-2-氨基-5-膦戊酸已被用于预处理 BNST(终纹床核),以阻止 ORX-A(食欲素-A)引入 BNST 的焦虑。

生化/生理作用

NMDA 拮抗剂具有肌肉松弛属性,对缺血引起的脑损伤具有神经元保护作用。2-氨基-5-膦甲酸已被证明可以阻断离子导入引起的 NMDA 的去极化。
抗惊厥药;强效和选择性N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂;2-氨基-5-膦酰戊酸的活性对映体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


从最新的版本中选择一种:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

其他客户在看

Slide 1 of 2

1 of 2

Synaptic Plasticity and Learning: Selective Impairment of Learning in
Rats and Blockade of Long-Term Potentiation in viva by the
IV-Methyl-D-Aspartate Receptor Antagonist AP5
R. G. M. Morris
The Journal of Neuroscience, 9(9), 3040-3057 (1989)
Paola Conti et al.
European journal of medicinal chemistry, 42(8), 1059-1068 (2007-03-10)
Twelve novel conformationally constrained homologues of glutamic acid have been synthesized and pharmacologically characterized at ionotropic glutamate receptors (iGluRs). Synthesis of the target compounds involved 1,3-dipolar cycloaddition of nitrile oxides to suitable dipolarophiles. The structure to the compounds has been
Orexin-A Induces Anxiety-like Behavior through Interactions with Glutamatergic Receptors in the Bed Nucleus of the Stria Terminalis of Rats
Elizabeth A Lungwitz
Physiology & Behavior, 107(5), 726-732 (2012)
Excitatory amino acid transmitters.
J C Watkins et al.
Annual review of pharmacology and toxicology, 21, 165-204 (1981-01-01)
Daniela Gandolfi et al.
Frontiers in cellular neuroscience, 11, 184-184 (2017-07-14)
The induction of long-term potentiation and depression (LTP and LTD) is thought to trigger gene expression and protein synthesis, leading to consolidation of synaptic and neuronal changes. However, while LTP and LTD have been proposed to play important roles for

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门