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Merck

A7219

Sigma-Aldrich

L-天冬氨酸

from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

别名:

(S)-(+)-氨基琥珀酸, (S)-氨基丁二酸

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About This Item

线性分子式:
HO2CCH2CH(NH2)CO2H
CAS号:
分子量:
133.10
Beilstein:
1723530
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.75

生物源

non-animal source

agency

meets EP testing specifications
meets USP testing specifications

化驗

98.5-101.0%

形狀

powder

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

顏色

white to off-white

mp

>300 °C (dec.) (lit.)

溶解度

1 M HCl: 100 mg/mL

SMILES 字串

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI 密鑰

CKLJMWTZIZZHCS-REOHCLBHSA-N

基因資訊

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一般說明

天冬氨酸(ASP)是一种非必需氨基酸,由哺乳动物自然产生。ASP是蛋白质的20个基本氨基酸之一,并有一个字母代码D。L-天冬氨酸可通过使用天冬氨酸酶的酶促过程进行工业化生产。

應用

L-天冬氨酸已用作:
  • 阿斯巴甜(ASP)代谢物(ASP),以测定乳鼠海马匀浆中乙酰胆碱酯酶(AChE)的活性
  • 印染趋化受体,以利用高通量技术筛选趋化受体并验证与表面等离子体共振(SPR)和核磁共振(NMR)的相互作用
  • 杜皮克氏′改良爱哥尔氏培养基′(DMEM)的补充剂,以用于各种培养细胞系的补充试验

生化/生理作用

快速兴奋突触的主要神经递质。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Florinda Meléndez-Rodríguez et al.
Cell reports, 26(9), 2257-2265 (2019-02-28)
Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire aspartate biosynthesis to control cell growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor cell proliferation. Here, we discovered that HIF1α acts as a direct repressor of aspartate
Aspartic acid
Johnson EC
reference module in biomedical sciences (2017)
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1512, 51-63 (2016-11-26)
Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and
Florinda Meléndez-Rodríguez et al.
Cell reports, 26(9), 2257-2265 (2019-02-28)
Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire aspartate biosynthesis to control cell growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor cell proliferation. Here, we discovered that HIF1α acts as a direct repressor of aspartate
Hongyu Ding et al.
Science advances, 7(47), eabk1023-eabk1023 (2021-11-18)
[Figure: see text].

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