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一般說明
Angiogenin is a secreted growth factor. It is localized in the tissue fluids such as plasma, amniotic fluid, cerebrospinal fluid and tumor microenvironment.
應用
Angiogenin human has been used to treat chicken eggs to determine its activity by chorioallantoic membrane (CAM) analysis . It has also been used to determine the angiogenic activity of Candida albicans and Streptococcus pneumoniae cultures by chicken chorioallantoic membrane assay .
生化／生理作用
Angiogenin plays a role in several biological functions such as tumorigenesis, innate immunity, neuroprotection. It also plays a role in reproduction, regeneration of damaged tissues and neovascularization.
Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily.
Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily. Although the ribonucleolytic activity of angiogenin toward most RNase A substrates is lower than that of RNase A, this activity is essential to its angiogenic activity since inhibition of the angiogenin RNase activity will inhibit the angiogenic activity. High affinity receptors for angiogenin are expressed in cultured aortic smooth muscle cells and can be modulated by protamin, heparin and placental ribonuclease inhibitor.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
分析報告
The activity of human angiogenin is tested in culture by measuring its ribonucleolytic activity for yeast tRNA.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
J Badet
Pathologie-biologie, 47(4), 345-351 (1999-06-18)
Angiogenin is a heparin-binding 14 kDa plasma protein with angiogenic and ribonucleolytic activity. Although its structural features have been extensively studied, an understanding of its physiological role and of how its properties are expressed continues to elude researchers. This article
D J Strydom
Cellular and molecular life sciences : CMLS, 54(8), 811-824 (1998-10-07)
The angiogenic and other biological functions of the angiogenins, members of the pancreatic RNase superfamily of proteins, are reviewed in the context of their primary and tertiary structures. The ribonucleolytic activity and interactions with the placental ribonuclease inhibitor have seen
Human angiogenin lacks specific antimicrobial activity
Avdeeva, Svetlana V, et al.
Current Microbiology, 53(6), 477-478 (2006)
E Hatzi et al.
European journal of biochemistry, 260(3), 825-832 (1999-04-02)
Human angiogenin is a plasma protein with angiogenic and ribonucleolytic activities. Angiogenin inhibited both DNA replication and proliferation of aortic smooth muscle cells. Binding of 125I-angiogenin to bovine aortic smooth muscle cells at 4 degrees C was specific, saturable, reversible
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