A5513

N-乙酰普鲁卡因胺 盐酸盐

≥99% (HPLC), powder

• 别名: N-乙酰普卡胺 盐酸盐, NAPA, 乙酰卡尼 盐酸盐
• 线性分子式: 4-(CH₃CONH)C₆H₄CONHCH₂CH₂N(C₂H₅)₂·HCl
• CAS号: 34118-92-8
• 分子量: 313.82
• EC號碼: 251-831-2
• MDL號碼: MFCD00012501
• 分類程式碼代碼: 12352100
• PubChem物質ID: 24890983
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: powder
• mp: 184-186 °C (lit.)
• 溶解度: H₂O: 50 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: Cl[H].CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
• InChI: 1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H
• InChI 密鑰: IYEWBJUCJHKLHD-UHFFFAOYSA-N

说明

應用

N-Acetylprocainamide hydrochloride may be used:

• as an internal standard for spiking plasma samples for ultra-high-pressure liquid chromatography coupled with a diode array detector (UHPLC-DAD) analysis
• to test its relaxant effect on tracheal smooth muscle tissue preparations
• in preparation of complexes with N-acetyl-L-tyrosine methyl ester and N-acetyl-L-phenylalanine methyl ester for studying intermolecular interactions using nuclear magnetic resonance (NMR) spectroscopy studies

N-Acetylprocainamide hydrochloride is a class III antiarrhythmic compound. N-Acetylprocainamide hydrochloride has been used in a study to determine the disposition of procainamide and N-acetylprocainamide in protein-calorie malnutrition. N-Acetylprocainamide hydrochloride has also been used to study pharmacokinetics of procainamide and N-acetylprocainamide in rats.

生化／生理作用

III 类抗心律失常药。通过降低延时的外向钾电流、稍微降低钙电流以及稍微抑制内向整流钾电流来增大动作电位的持续时间。这是普鲁卡因胺的活性代谢物，不会导致全身性红斑狼疮。

作用于钾电流的 III 类抗心律失常药。

N-acetyltransferase II in liver catalyzes the conversion of procainamide to N-acetylprocainamide (NAPA).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)